Table 3. P. aeruginosa-induced proteins in octr-1(ok371) animals.
| Biological Functions | Protein | Gene ID | Description | Fold Change# | p-Value |
|---|---|---|---|---|---|
| Innate immune response | DOD-24 | c32h11.12 | CUB-like domain | infected only | |
| F55G11.2 | f55g11.2 | CUB-like domain | infected only | ||
| F55G11.4 | f55g11.4 | CUB-like domain | infected only | ||
| C32H11.4 | c32h11.4 | CUB-like domain | infected only | ||
| DOD-17 | k10d11.1 | CUB-like domain | infected only | ||
| CLEC-67 | f56d6.2 | C-type lectin | infected only | ||
| CLEC-66 | f35c5.9 | C-type lectin | infected only | ||
| CLEC-63 | f35c5.6 | C-type lectin | 3.5 | 6.05E-03 | |
| SKPO-1 | f49e12.1 | ShK toxin domain | infected only | ||
| C14C6.5 | c14c6.5 | ShK toxin domain | infected only | ||
| LYS-2 | y22f5a.5 | lysozyme | infected only | ||
| GST-38 | f35e8.8 | glutathione S-transferase | infected only | ||
| GST-5 | r03d7.6 | glutathione S-transferase | 9.5 | 6.98E-03 | |
| GST-4 | k08f4.7 | glutathione S-transferase | 2.8 | 9.81E-03 | |
| GST-7 | f11g11.2 | glutathione S-transferase | 3.9 | 9.31E-03 | |
| GCS-1 | f37b12.2 | glutathione biosynthesis | 2.7 | 8.72E-03 | |
| ASP-14 | k10c2.3 | aspartyl protease | 7.2 | 5.77E-03 | |
| M60.2 | m60.2 | ortholog of human endonuclease, polyU-specific | infected only | ||
| C17H12.8 | c17h12.8 | involved in innate immune response | infected only | ||
| F35E12.6 | f35e12.6 | involved in innate immune response | infected only | ||
| IRG-3 | f53e10.4 | infection response protein | infected only | ||
| SKR-3 | f44g3.6 | skp1 related (ubiquitin ligase complex component) | 2.3 | 6.32E-03 | |
| DJR-1.1 | b0432.2 | glutathione-independent glyoxalase DJR-1.1 | 1.8 | 2.25E-03 | |
| Sulfur amino acid biosynthesis | METR-1 | r03d7.1 | probable methionine synthase | infected only | |
| C01G10.9 | c01g10.9 | methylthioribose-1-phosphate isomerase | infected only | ||
| F58H1.3 | f58h1.3 | enolase-phosphatase E1 | 2.5 | 8.81E-05 | |
| SAMS-4 | c06e7.3 | probable S-adenosylmethionine synthase 4 | 1.8 | 9.82E-03 | |
| CTH-2 | zk1127.10 | putative cystathionine gamma-lyase 2 | 4.1 | 6.44E-03 | |
| CYSL-2 | k10h10.2 | bifunctional L-3-cyanoalanine synthase/cysteine synthase | 2.3 | 1.71E-04 | |
| HMG-11 | t05a7.4 | predicted to have DNA binding activity | infected only | ||
| Translation/protein synthesis | RPL-18 | y45f10d.12 | 60S ribosomal protein L18 | 2.1 | 5.23E-03 |
| RPS-10 | d1007.6 | ribosomal protein, small subunit | 2.1 | 5.22E-03 | |
| RPL-13 | c32e8.2 | 60S ribosomal protein L13 | 2.0 | 7.94E-03 | |
| RPS-11 | f40f11.1 | ribosomal protein, small subunit | 1.7 | 7.59E-03 | |
| RPS-1 | f56f3.5 | 40S ribosomal protein S3a | 1.6 | 8.48E-03 | |
| RPS-28 | y41d4b.5 | 40S ribosomal protein S28 | 1.4 | 9.56E-03 | |
| MRPL-12 | w09d10.3 | mitochondrial ribosomal protein, large | 2.5 | 5.09E-03 | |
| RUVB-1 | c27h6.2 | RuvB-like 1 | infected only | ||
| EIF-3.J | y40b1b.5 | eukaryotic initiation factor | 1.7 | 4.35E-03 | |
| K07C5.4 | k07c5.4 | ortholog of human NOP56 ribonucleoprotein | 1.5 | 9.73E-03 | |
| SRP-6 | c03g6.19 | serpin (serine protease inhibitor) | infected only | ||
| proteolysis/hydrolysis | KLO-1 | c50f7.10 | KLOtho (mammalian aging-associated protein) homolog | 2.6 | 1.74E-03 |
| F13H6.3 | f13h6.3 | ortholog of human carboxylesterase 2 | 2.3 | 4.69E-03 | |
| TAX-6 | c02f4.2 | Serine/threonine-protein phosphatase | 2.0 | 8.34E-03 | |
| Y25C1A.13 | y25c1a.13 | ortholog of human enoyl CoA hydratase 1 | 2.0 | 9.29E-03 | |
| PAM-1 | f49e8.3 | puromycin-sensitive aminopeptidase | 1.8 | 2.09E-03 | |
| T22C1.6 | t22c1.6 | ortholog of human taxilin α, β, and γ | infected only | ||
| ER/UPR | Y41C4A.11 | y41c4a.11 | involved in ER UPR | 4.3 | 1.84E-03 |
| C14B9.2 | c14b9.2 | probable protein disulfide-isomerase A4 | 2.3 | 1.52E-03 | |
| HSP-4 | f43e2.8 | heat shock protein | 2.2 | 2.00E-03 | |
| PDI-1 | c14b1.1 | protein disulfide isomerase | 1.6 | 8.26E-03 | |
| SNA-1 | w02f12.6 | snRNP-binding protein | infected only | ||
| Transcription | HRP-1 | f42a6.7 | putative hnRNP | 5.5 | 6.47E-05 |
| T13F2.2 | t13f2.2 | predicted to have transcription coactivator activity | 3.3 | 1.74E-03 | |
| RPB-2 | c26e6.4 | RNA polymerase II (B) subunit | 3.1 | 3.22E-05 | |
| RPB-9 | y97e10ar.5 | RNA polymerase II (B) subunit | 2.5 | 6.86E-03 | |
| CEY-4 | y39a1c.3 | C. elegans Y-box | 2.0 | 1.05E-04 | |
| CEY-2 | f46f11.2 | C. elegans Y-box | 1.7 | 3.55E-03 | |
| CPG-2 | b0280.5 | chondroitin proteoglycan | infected only | ||
| Development/reproduction | C29E4.12 | c29e4.12 | ortholog of human C7orf55 | infected only | |
| Y18D10A.9 | y18d10a.9 | ortholog of human CIAO1 | infected only | ||
| T23D8.3 | t23d8.3 | ortholog of human and yeast LTV1 | infected only | ||
| K07H8.10 | k07h8.10 | predicted to have necleic acid and nucleotide binding activity | 8.2 | 1.56E-05 | |
| F55B11.2 | f55b11.2 | development | 4.4 | 9.81E-03 | |
| DNC-2 | c28h8.12 | dynactin complex component | 3.2 | 3.30E-03 | |
| F32A11.3 | f32a11.3 | involved in reproduction | 3.2 | 9.82E-03 | |
| Y71F9AL.9 | y71f9al.9 | ortholog of human SPATS2L and SPATS2 | 2.1 | 4.21E-04 | |
| DPY-30 | zk863.6 | dosage compensation protein | 2.0 | 4.34E-03 | |
| PRX-19 | f54f2.8 | Peroxisome assembly factor | 1.9 | 9.17E-03 | |
| MRPS-28 | y43f8c.8 | Mitochondrial ribosomal Protein | 1.8 | 1.63E-03 | |
| C44E4.4 | c44e4.4 | ortholog of human Sjogren syndrome atigen B | 1.6 | 7.28E-03 | |
| F20D6.11 | f20d6.11 | putative FAD-binding oxidoreductase | infected only | ||
| Cell redox homeostasis | F29C4.2 | f29c4.2 | ortholog of human cytochrome c oxidase subunit Vic | infected only | |
| Y47G6A.21 | y47g6a.21 | predicted to have oxidoreductase activity | 2.8 | 1.91E-03 | |
| F45H10.3 | f45h10.3 | predicted to have NADH dehydrogenase (ubiquinone) activity | 2.6 | 7.79E-03 | |
| PRDX-6 | y38c1aa.11 | preoxiredoxin 6 | 1.7 | 6.03E-03 | |
| KIN-10 | t01g9.6 | protein kinase | infected only | ||
| Protein Kinase | CAT-4 | f32g8.6 | GTP cyclohydrolase 1 | infected only | |
| MMCM-1 | zk1058.1 | methylmalonyl-CoA mutase homolog | 5.4 | 4.87E-03 | |
| compound metabolic process | C36A4.4 | c36a4.4 | probable UDP-N-acetylglucosamine pyrophosphorylase | 2.7 | 4.17E-03 |
| C39D10.7 | c39d10.7 | involved in chitin metabolic process | 2.0 | 6.91E-03 | |
| ZK1307.8 | zk1307.8 | ortholog of human protein kinase C substrate 80K-H | 1.8 | 8.37E-03 | |
| CTS-1 | t20g5.2 | citrate synthase | 1.7 | 4.81E-03 | |
| DPYD-1 | c25f6.3 | dihydropyrimidine dehydrogenase | 1.7 | 5.14E-03 |
#Infected only: the protein was only detected in the infected animals, not in the uninfected animals.