TABLE 3.
Summary of preclinical molecular-based studies that used normal, diabetic, and obese rodent models1
| Study authors, year (ref) | Model and health status | Tissue type | Xenobiotic, tran sport, and metabolizing system | Direction of change |
| Wang et al., 2002 (66) | Male Wistar STZ-induced diabetic rats | Liver | COMT activity | ↓ |
| Braun et al., 1998 (67) | Male B/Wor diabetic rats | Liver | Ugt1a1 mRNA, protein, activity | ↑ |
| Burant et al., 1994 (68) | Male Sprague-Dawley STZ-induced diabetic rats | Enterocytes | Glut2, Glut5, Sglt1 mRNA and protein | ↑ |
| Maeng et al., 2007 (69) | Male Sprague-Dawley STZ-induced diabetic rats | Brain | P-gp protein | ↑ |
| Zhang et al., 2011 (70) | Male Sprague-Dawley STZ-induced diabetic rats | Liver | Abcb1a, Abcb1b mRNA and protein (P-gp) | No change |
| P-gp protein | No change | |||
| Intestinal mucosa | Abcb1a, Abcb1b mRNA and protein (P-gp) | ↓ | ||
| Kidney | Abcb1a mRNA | ↑ | ||
| Abcb1b mRNA | No change | |||
| P-gp protein | ↑ | |||
| Liu et al. 2006 and 2007 (71, 72) | Male Sprague-Dawley and ICR STZ-induced diabetic rats | Brain cortex | P-gp protein | ↓ |
| Nawa et al., 2010 (73) | Male ddY STZ-induced diabetic mice | Ileum | P-gp protein | ↓ |
| van Waarde et al., 2002 (74) | Male Wistar STZ-induced diabetic rats | Liver | Mdr2 mRNA and protein | ↑ |
| Liver | Mrp2 mRNA | No change | ||
| Mrp2 protein | ↓ | |||
| Nikooie et al., 2013 (75) | Male Wistar STZ-induced diabetic rats | Soleus muscle | Mct1 mRNA and protein | ↓ |
| Yu et al., 2010 (62) | Male Sprague-Dawley STZ-induced diabetic rats | Small intestine | P-gp protein | ↓ |
| Liu et al., 2012 (63) | Male Wistar STZ-induced diabetic rats | Duodenum and jejunum | Mdr1a and Mdr1b (P-gp) mRNA | ↓ |
| Ileum | Mdr1a and Mdr1b (P-gp) mRNA | ↑ | ||
| Liver | Comt mRNA | ↓ | ||
| Liver | Ugt1a3, Ugt1a7, Ugt2b3, Ugt2b6, Ugt2b12 mRNA | ↑ | ||
| Liver | Ugt2b3 and Ugt2b8 mRNA | ↓ | ||
| Liver | Sult1b1 mRNA | ↓ | ||
| Kang et al., 2010 (64) | Male Sprague-Dawley STZ-induced diabetic rats | Liver | UDP-glucuronic acid concentrations | ↑ |
| Intestine | UDP-glucuronic acid concentrations | No change | ||
| Hasegawa et al., 2010 (65) | Male Donryu STZ-induced diabetic rats | Glucuronidation probed by using morphine | UGT | ↑ |
| Liver | Ugt2b1 mRNA | ↑ | ||
| Liver | Mrp2 mRNA | ↓ | ||
| Mrp3 mRNA | ↑ | |||
| Kim et al., 2004 (76) | Male Sprague-Dawley vs. obese Zucker rats | Liver | Ugt1a1, Ugt1a6, Ugt2b1, Mrp2 mRNA | ↓ |
| Xu et al., 2012 (77) | Male obese C57BL/6J Lepob/ob mice | Liver | Ugt1a1, Ugt1a6, Ugt1a9, Ugt2a3, Ugt3a1, Ugt3a2 mRNA | ↑ |
| Liver | Ugt2b1 mRNA | ↓ | ||
| Lucas-Teixeira et al., 2002 (78) | Obese Zucker rats | Jejunal mucosa | COMT activity | ↑ |
| Koide et al., 2011 (79) | Male C57BL/6J diet-induced obese rats | Liver | Total UGT activity | ↑ |
| Liver | Sult2a1 protein and activity | ↓ | ||
| Kim et al., 2004 (80) | Female C57BL/6 mice treated with LPS | Liver | Sult2a1 mRNA and total SULT activity | ↓ |
| Shimada et al., 1999 (81) | Male Sprague-Dawley rats treated with LPS | Liver | Total SULT activity | ↓ |
| Ho and Piquette-Miller, 2007 (82) | Male Sprague-Dawley rats treated with LPS | Liver | Mdr1b mRNA | ↑ |
1
Abc, ATP-binding cassette transporter; COMT, catechol-O-methyltrasferase; Glut, glucose transporter; Mct1, monocarboxylate transporter 1; Mdr, multidrug resistance protein; Mrp, multidrug resistance–associated protein; P-gp, P-glycoprotein; ref, reference; Sglt1, sodium-dependent glucose transporter 1; STZ, streptozocin; SULT, sulfotransferase; UGT, UDP-glucuronyltransferase; ↓, decrease; ↑, increase.