TABLE 11.

Comparing GRADE quality of evidence with meta-evidence judgment based on the NutriGrade¹

Comparison outcome reference	Study design	GRADE quality of evidence	NutriGrade	Meta-evidence judgment
Low saturated fat compared with usual diet	MA of RCTs	Moderate	7.3	Moderate
Outcome: all-cause mortality
(6)
Paleolithic diet	MA of RCTs	Moderate	5.75	Low
Outcome: waist circumference
(46)
High- vs. low-protein diet	MA of RCTs	Moderate	4.05	Low
Outcome: weight loss
(47)
High- vs. low-fat diet	MA of RCTs	Moderate	6.8	Moderate
Outcome: TGs
(48)
Low-carbohydrate vs. balanced diet	MA of RCTs	Moderate	5.35	Low
Diastolic blood pressure
(49)
High- vs. low-saturated fat	MA of cohort studies	Very low	4.5	Low
Outcome: all-cause mortality
(5)
High vs. low coffee intake	MA of cohort studies	Low	7.3	Moderate
Outcome: endometrial cancer
(50)
High vs. low sodium intake	MA of cohort studies	Very low	5.55	Low
Outcome: stroke
(51)
High vs. low intake of sugar-sweetened beverages in children	MA of cohort studies	Low	4.5	Low
Outcome: adiposity
(52)
High vs. low potassium intake	MA of cohort studies	Low	5.9	Low
Outcome: stroke
(53)

¹GRADE, Grading of Recommendations Assessment, Development and Evaluation; MA, meta-analysis; RCT, randomized controlled trial.