Skip to main content
. 2016 Nov 11;6:36803. doi: 10.1038/srep36803

Figure 6. Working model: miR-208a titration and contractile function.

Figure 6

Cardiac expression of miR208a suppresses PDE4D through engagement of the seed sequence of miR-208a to the seed-match sequence of PDE4D 3′ UTR. MiR-208a also up-regulates other miRs targeting PDE4D. Suppression of PDE4D by miR-208a and other miRs promotes increased phosphorylation of cTnI and PLN thereby enhancing cardiac function (A, Green). Baseline contractility is depicted in red (A). Suppression of regulatory subunit of PKA (PRKAR1α) by miR-208a leads to active catalytic subunit (PRKCA) and PKA activation (B). This concerted amplification of PKA signaling in turn increases phosphorylation of cTnI and PLN thereby enhancing cardiac function (A, green and B). The dotted line indicates indirect regulation.