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. 2016 Nov 11;6:36903. doi: 10.1038/srep36903

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Copyright © 2016, The Author(s)

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(a–e) Effect of Se-lactoferrin on corneal erosion in the TS exposure dry eye rat model. (a–d) Photographs of cornea stained by fluorescein after treatment with eye drops for 5 days. (a) PBS treatment in Se-lactoferrin group. (b) Se-lactoferrin eye drops in Se-lactoferrin group. (c) PBS treatment in Diquas group. (d) Diquas eye drops in Diquas group. (e) Fluorescein score of cornea in the eyes of dry eye rats treated with 0.1% Se-lactoferrin (Se-LF), 3% Diquas (Diq), or PBS. Results are expressed as mean ± S.D. Dunnett’s test was used to determine the significance of differences. ***Indicates a significant difference from the result in PBS treatment of the same group, P < 0.005. f: Effect of Se-lactoferrin on corneal disorder in the short-term dry eye model in rabbits. The eyes of rabbits were held open with an eyelid speculum to desiccate them. Rabbits were treated with PBS, 0.1% Se-lactoferrin (Se-LF), 3% Diquas (Diq), or 0.3% Hyalein (HA). Undesiccated eyes were eyes that were not held open by an eyelid speculum and received no eye drop treatments. All data are presented as mean ± S. D. (n = 9–10). ^##P < 0.01, compared with the undesiccated eyes (Student’s t-test) **P < 0.01, compared with the PBS-treated eyes (Dunnett’s test).