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. 2016 Nov 11;6:36603. doi: 10.1038/srep36603

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) samples’ predicted probabilities of being severe. (b) shows the ROC curve and the AUC for predicted probabilities. The AUC value of approximately 1 indicates how accurate our signature performs on this internal validation set. (c) shows that a genomic model from the age by sex standardized data out performs that from the unstandardized data. In addition, there is a significant difference between a model with clinical parameters and that with a genomic score and just a slight improvement when both parameters are included in a model.