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. 2016 Nov 11;6:36650. doi: 10.1038/srep36650

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Copyright © 2016, The Author(s)

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Transmission electron microscopy (TEM) images of (a) non-dextran-coated iron oxide nanoparticles and (b) dextran-coated monocrystalline iron oxide nanoparticles (MION), with their diagrammatic representations ((a′) non-dextran-coated iron oxide nanoparticles and (b′) dextran-coated MION) illustrating the aggregation/non-aggregation and uniformity/non-uniformity of shape of nanoparticles. (c) High resolution TEM (HRTEM) image of the dextran-coated MION showing the crystal lattice planes of the individual particles confirming the monocrystalline property of the nanoparticles, red arrows point to the lattice planes. (d,e) Size distribution of the MION obtained from the dynamic light scattering (DLS) (d) and TEM images (e). DLS showed the diameter of nanoparticles to be 6.06 ± 0.9 nm, while TEM images showed nanoparticles of 4.28 ± 1.1 nm diameter. Red line curves denote log-normal fit with narrow size distribution.