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. 2016 Nov 8;7:13234. doi: 10.1038/ncomms13234

Figure 5. H2O2-induced potentiation of sensory behavior and ASH neuron function requires AKT-1.

Figure 5

(a) H2O2-induced behavioral potentiation requires AKT-1 but not AKT-2. In akt-1(mg306) but not akt-2(ok391) mutant worms, H2O2 treatment failed to promote osmotic avoidance behavior. This phenotype was rescued by a transgene expressing akt-1 cDNA in ASH neurons driven by the sra-6 promoter. n≥20; **P<0.005, ***P<0.0005 (ANOVA); Error bars: s.e.m. (b–d) H2O2-induced potentiation of ASH sensory response requires AKT-1 but not AKT-2. In akt-1 mutant worms, H2O2 treatment can no longer promote ASH calcium response to glycerol stimulus (b). No such defect was detected in akt-2(k391) mutant worms. Shades along the traces in (b) and (c) represent error bars (s.e.m.). Bar graph in (d) summarizes the data in (b) and (c). n≥9; Error bars: s.e.m. *P<0.05 (ANOVA).