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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Am J Med Genet C Semin Med Genet. 2016 Apr 20;172(2):129–137. doi: 10.1002/ajmg.c.31490

Figure 2. Functional interactions between Polycomb Group silencing and cohesin.

Figure 2

Cohesin recruits the PRC1 Polycomb complex to active genes via direct interactions, and thereby controls how much PRC1 is available for silencing. This model is consistent with the in vivo antagonism between Polycomb silencing and cohesin, described in the text. The PRC1 at active genes influences RNA polymerase function, and may serve to govern cohesin’s ability to promote transition of paused polymerase into elongation (Dorsett and Kassis, 2014). This diagram is modified from Schaaf et al., 2013b.