Figure 4. Integrative analysis of rhEPO using both high-resolution native MS and middle-down proteomics data.

(a,b) Comparison of the in silico constructed spectrum based on middle-down proteomic data (shown in blue) with the experimental native MS spectrum (shown in brown) before (a) or after (b) sialidase treatment. The Pearson correlation coefficient between the displayed spectra is shown at the top right.