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. 2016 Nov 8;7:13436. doi: 10.1038/ncomms13436

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a–f) ApoE^−/− mice were conditioned with PBS or super-low-dose LPS together with HFD for 8 weeks. (a) Representative images of atherosclerotic plaques within aortic root areas stained by Oil Red O. Scale bar, 300 μm. (b) Ratios of the lipid deposition area among the total atherosclerotic plaque area within the aortic root from PBS mice (n=6) and super-low-dose LPS-conditioned mice (n=6). (c) Representative images of necrotic core areas within the aortic roots. Scale bar, 100 μm. (d) Ratios of the necrotic area among the total atherosclerotic plaque area from PBS (n=12) and super-low-dose LPS-conditioned (n=6) mice. (e) Representative images of collagen containing areas within aortic roots. Scale bar, 100 μm. (f) Ratios of the collagen-containing area among the total atherosclerotic plaque area within the aortic root from PBS (n=5) and super-low-dose LPS-conditioned (n=5) mice. (g–l) ApoE^−/− mice were pre-conditioned with PBS or super-low-dose LPS for 4 weeks together with HFD, followed by HFD feeding only for an additional 4 weeks. (g) Representative images of atherosclerotic plaques within aortic root areas stained by Oil Red O. Scale bar, 300 μm. (h) Quantification of the lipid deposition area as a percentage of the total atherosclerotic plaque area within the aortic root from PBS (n=7) and super-low-dose LPS-conditioned (n=7) mice. (i) Representative images of necrotic core areas within the aortic roots. Scale bar, 100 μm. (j) Ratios of the necrotic area among the total atherosclerotic plaque area within the aortic root from PBS (n=5) and super-low-dose LPS-conditioned (n=5) mice. (k) Representative images of collagen containing areas within aortic roots. Scale bar, 100 μm. (l) Ratios of the collagen containing area among the total atherosclerotic plaque area within the aortic root from PBS (n=7) and super-low-dose LPS-conditioned (n=7) mice. Error bars show means±s.e.m. All data are representative of at least two similar experiments. *P<0.05 and **P<0.01; Student's t-test.

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