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BIO-11006 attenuates LPS-induced NF-κB activation in lung, measured 72 hours after LPS instillation, at each time point of initiation of treatment. NF-κB activation was assessed via phospho–NF-κB p65 analysis by immunoblotting. Actin was used as a loading control (lower panel). BIO-11006 clearly attenuates NF-κB activation in response to LPS at each time point.
