Figure 6. Syngap1 haploinsufficiency in MGE-derived interneurons impairs cortical gamma oscillations during active exploration in awake mice.

(a,b) Representative examples of EEG recordings from the cortex of adult (a) Syngap1^flox/+ and (b) Tg(Nkx2.1-Cre);Syngap1^flox/+mice with corresponding spectrogram. Note that although theta oscillations (red boxes) are detected in both animals, gamma power is lower in Tg(Nkx2.1-Cre);Syngap1^flox/+during these oscillations. (c) Bar graph showing the average power in the gamma frequency band in the cortex and the hippocampus for both groups. Note that in both regions, Tg(Nkx2.1-Cre);Syngap1^flox/+ showed less power in the gamma frequency band (Wilcoxon rank sum tests, *P=0.005, **P=0.0006). n=3 mice for both genotype.