Fig. 1.

miR-375 expression in PC tissues and its response to docetaxel PC cell lines. a Overexpression of miR-375 in PC tissues. Normalized miR-375 expression levels were downloaded from TCGA. Compared to normal prostate tissues, expression levels of miR-375 in PC tissues are significantly higher. Number on the top of each box plot is mean value of miR-375 expression. b Response of miR-375 to docetaxel in PC cells. miR-375 expression levels were measured by qRT-PCR under different concentrations of docetaxel. The result shows dose-dependent upregulation of miR-375. Number on the top of each bar plot is mean fold change of miR-375 expression when compared to controls. c Dynamic expression changes of miR-375 during and after docetaxel treatment. 1 nM docetaxel was used until 72 h. Expression level was measured at days 0, 3, 7, 14, and 21, respectively. miR-375 expression was upregulated during treatment and gradually reduced after removal of docetaxel. MicroRNA expression values were rescaled relative to the blank control