Table 7.
Twenty-four month change in semi-quantitative MRI biomarkers – BMLs
| MRI feature | Biomarker | Overall n (%) | Controls | Cases | p-value |
|---|---|---|---|---|---|
| BML | Change in Number of subregions affected by any BML (BL to 24 M) | ||||
| -3 | 4 (1 %) | 3 (0.7 %) | 1 (0.5 %) | ||
| -2 | 6 (1 %) | 4 (1.0 %) | 2 (1.0 %) | ||
| -1 | 71 (12 %) | 48 (11.9 %) | 23 (11.9 %) | ||
| 0 | 309 (52 %) | 214 (52.8 %) | 95 (49.0 %) | ||
| 1 | 154 (26 %) | 105 (25.9 %) | 49 (25.3 %) | ||
| 2 | 43 (7 %) | 24 (5.9 %) | 19 (9.8 %) | ||
| 3 | 9 (2 %) | 7 (1.7 %) | 2 (1.0 %) | ||
| 4 | 2 (0 %) | 0 (0.0 %) | 2 (1.0 %) | ||
| 5 | 1 (0 %) | 0 (0.0 %) | 1 (0.5 %) | ||
| Change in Number of subregions affected by any BML (BL to 24 M) | 0.318 | ||||
| Improvement | 81 (14 %) | 55 (13.6 %) | 26 (13.4 %) | ||
| No Change | 309 (52 %) | 214 (52.8 %) | 95 (49.0 %) | ||
| Worsen in 1 subregion | 154 (26 %) | 105 (25.9 %) | 49 (25.3 %) | ||
| Worsen in 2+ subregions | 55 (9 %) | 31 (7.7 %) | 24 (12.4 %) | ||
| Maximum worsening in BML score of all subregions in knee (BL to 24 M) | 0.003* | ||||
| 0 | 191 (32 %) | 138 (34.1 %) | 53 (27.3 %) | ||
| 1 | 36 (6 %) | 24 (5.9 %) | 12 (6.2 %) | ||
| 2 | 273 (46 %) | 192 (47.4 %) | 81 (41.8 %) | ||
| 3 | 99 (17 %) | 51 (12.6 %) | 48 (24.7 %) | ||
| Number of subregions with any improvement in BML (including within grade changes – BL to 24 months) | |||||
| 0 | 308 (51 %) | 219 (53.9 %) | 89 (45.9 %) | ||
| 1 | 192 (32 %) | 132 (32.5 %) | 60 (30.9 %) | ||
| 2 | 76 (13 %) | 42 (10.3 %) | 34 (17.5 %) | ||
| 3 | 18 (3 %) | 11 (2.7 %) | 7 (3.6 %) | ||
| 4 | 4 (1 %) | 2 (0.5 %) | 2 (1.0 %) | ||
| 5 | 1 (0 %) | 0 (0.0 %) | 1 (0.5 %) | ||
| 6 | 1 (0 %) | 0 (0.0 %) | 1 (0.5 %) | ||
| Any subregions with improvement (including within grade changes) in BML | 0.065 | ||||
| No | 308 (51 %) | 219 (53.9 %) | 89 (45.9 %) | ||
| Yes | 292 (49 %) | 187 (46.1 %) | 105 (54.1 %) | ||
| Number of subregions with any worsening (including within grade changes) in BML | |||||
| 0 | 191 (32 %) | 138 (34.0 %) | 53 (27.3 %) | ||
| 1 | 194 (32 %) | 143 (35.2 %) | 51 (26.3 %) | ||
| 2 | 128 (21 %) | 79 (19.5 %) | 49 (25.3 %) | ||
| 3 | 53 (9 %) | 31 (7.6 %) | 22 (11.3 %) | ||
| 4 | 23 (4 %) | 9 (2.2 %) | 14 (7.2 %) | ||
| 5 | 10 (2 %) | 6 (1.5 %) | 4 (2.1 %) | ||
| 6 | 1 (0 %) | 0 (0.0 %) | 1 (0.5 %) | ||
| Any subregions with worsening (including within grade changes) in BML | 0.102 | ||||
| No | 191 (32 %) | 138 (34.0 %) | 53 (27.3 %) | ||
| Yes | 409 (68 %) | 268 (66.0 %) | 141 (72.7 %) |
*statistically significant at p < 0.05; p values refer to differences between cases and controls across all grades