Table 8.
Twenty-four month change in semi-quantitative MRI biomarkers – osteophytes
| MRI feature | Biomarker | Overall n (%) | Controls | Cases | p-value |
|---|---|---|---|---|---|
| Osteophytes | 24 M Increase in number of locations affected by any osteophyte | 0.386 | |||
| No | 544 (91 %) | 371 (91.4 %) | 173 (89.2 %) | ||
| Yes | 56 (9 %) | 35 (8.6 %) | 21 (10.8 %) | ||
| 24 M Change in number of locations affected by any Osteophyte | 0.585 | ||||
| No Change | 544 (91 %) | 371 (91.4 %) | 173 (89.2 %) | ||
| Worsen in 1 subregion | 32 (5 %) | 21 (5.2 %) | 11 (5.7 %) | ||
| Worsen in 2+ subregions | 24 (4 %) | 14 (3.4 %) | 10 (5.2 %) | ||
| 24 M Max change in osteophyte score across all locations in knee | |||||
| 0 | 498 (83 %) | 347 (85.5 %) | 151 (77.8 %) | ||
| 1 | 97 (16 %) | 55 (13.5 %) | 42 (21.6 %) | ||
| 2 | 5 (1 %) | 4 (1.0 %) | 1 (0.5 %) | ||
| 24 M Max change in osteophyte score > =1 across all locations in knee | 0.021* | ||||
| No | 498 (83 %) | 347 (85.5 %) | 151 (77.8 %) | ||
| Yes | 102 (17 %) | 59 (14.5 %) | 43 (22.2 %) |
*statistically significant at p < 0.05; p values refer to differences between cases and controls across all grades