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. 2016 Nov 1;26(11):1588–1597. doi: 10.1089/thy.2016.0247

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Copyright 2016, Mary Ann Liebert, Inc.

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FIG. 1. — Criteria to diagnose poorly differentiated thyroid carcinoma (PDTC). The Memorial Sloan Kettering Cancer Center (MSKCC) criteria require tumor necrosis or a mitotic index of ≥5/10 high power fields (HPFs). The Turin proposal requires solid/nested/insular growth pattern, and absence of nuclear features of papillary thyroid carcinoma (PTC), and at least one of the following three features: convoluted nuclei, mitotic index of ≥3/10 HPFs and/or tumoral necrosis. (A) Thyroid carcinoma displaying the nuclear features of PTC, as well as papillary architecture and tumor necrosis (N). This tumor will be classified as PDTC by MSKCC criteria and as PTC by the Turin proposal. (B) A thyroid carcinoma without the nuclear features of PTC demonstrating a solid growth pattern and a high mitotic index of 7/10 HPFs (arrows). This tumor will be classified as MSKCC-PDTC and Turin-PDTC.