FIG. 6.

Spinal cord injury (SCI) increases neuronal endoplasmic reticulum (ER) stress in the brain. (A–C) Quantification of ER stress marker 78-kDa glucose regulation protein (GRP78)+ cells showed significantly increased in the cortex, hippocampus, and thalamus in an injury severity–dependent manner. (D) Representative images of immunohistochemistry staining for GRP78 in the key brain regions from sham, mild, moderate, and severe SCI animals. (E) Quantification of GRP78+/ doublecortin (DCX)+ double-labeling cells in hippocampal DG. (F) A representative image for GRP78+/DCX+ cells from moderate SCI mice. (G) High-magnification image of GRP78 co-labeling with DCX from the insert in F. All scale bars are 50 μm. *p < 0.05, **p < 0.01, ***p < 0.001 vs. sham group. n = 6–7. Color image is available online at www.liebertpub.com/neu