TABLE 4.
Cytokine responses during early infection that correlate with the viral set point
| Virus and cytokine | R2 | P value | FDR |
|---|---|---|---|
| SIVsab9315BR | |||
| IL-6 | 0.85a | 0.009 | 0.07 |
| MCP-1 | 0.85 | 0.009 | 0.07 |
| sCD40L | 0.64 | 0.057 | 0.24 |
| IL-1β | 0.61 | 0.068 | 0.24 |
| IL-8 | 0.54 | 0.095 | 0.27 |
| SIVmac239Δnef | |||
| MCP-1 | 0.75 | 0.001 | 0.003 |
| sCD40L | 0.76 | 0.001 | 0.003 |
| IL-8 | 0.221 | 0.17 | 0.28 |
| SIVmac251 | |||
| IFN-γ | 0.83 | 0.0003 | 0.004 |
| IL-18 | 0.81 | 0.0004 | 0.004 |
| G-CSF | 0.64 | 0.006 | 0.04 |
| IL-15 | 0.59 | 0.009 | 0.05 |
| MIP-1β | 0.55 | 0.015 | 0.06 |
| SAA | 0.421 | 0.04 | 0.11 |
| MCP-1 | 0.405 | 0.048 | 0.11 |
| VEGF | 0.41 | 0.05 | 0.11 |
| IL-10 | 0.287 | 0.11 | 0.23 |
| IL-6 | 0.257 | 0.13 | 0.25 |
| MIP-1α | 0.246 | 0.145 | 0.25 |
a
For each analyte, the AUC was calculated for the first 4 weeks of infection, and a regression analysis was done comparing this value with set point viremia. Cytokines with nonsignificant P values (P values between 0.05 and 0.2, possibly representing a trend) and their associated values are italicized.