TABLE 1.

Characteristics of hMAbs from volunteers in the DP6-001 trial

Volunteer	hMAb	Wk	Epitope	Heavy chain			Light chain
				Germ line	Mutation %	CDR3	Germ line (chaina)	Mutation %	CDR3
ABL-034 (group A)	HH1G9	36	C2/C5	1-2*02	3	16	2-28*01 (K)	1	9
	HH2D11	36	NDb	1-2*02	3	19	3-11*01 (K)	0	8
	HH4E4	36	ND	1-46*01	5	18	7-43*01 (L)	2	11
ABL-001 (group B)	GB1	30	C2	1-69*9	6	18	1-5*03 (K)	4	6
	EA1	32	C5	1-69*01	2	19	3-10*01 (K)	<1	11
	EA7	32	ND	1-69*01	5	14	3-19*01 (L)	4	11
	EA8	32	ND	4-39*01	9	20	1-40*01 (L)	3	11
ABL-003 (group B)	CC3C2	36	ND	3-30*03	2	23	1-44*01 (L)	2	11
	CC6B5	36	C2	1-46*01	3	12	1-26*01 (K)	4	9
	CC6C11	36	ND	1-46*01	5	12	1D-17*02 (K)	1	9
ABL-040 (group C)	TA6	30	V3	1-3*01	5	18	3-10*01 (L)	3	11
	TA7	30	V3	1-3*01	4	17	3-10*01 (L)	1	11
	TB7	30	C2/C5	1-69*06	2	23	2-14*01 (L)	2	10

^aK, kappa chain; L, lambda chain.

^bND, not determined.