TABLE 3.
Neutralization titers of hMAb TA6 by TZM-bl cell assaya
| Study location, neutralization result, and virus | Clade | IC50 (μg/ml) |
|---|---|---|
| UMass | ||
| Positive neutralization | ||
| MN | B | 27.5 |
| SF162 | B | 3.67 |
| SS1196 | B | 2.23 |
| QH0692.42 | B | 31.8 |
| Negative neutralization | ||
| NL4-3 | B | >50 |
| SC422661 | B | >50 |
| WITO4160 | B | >100 |
| ZM109F.PB4 | C | >50 |
| Du156 | C | >50 |
| Du422.1 | C | >100 |
| ZM197.pB7 | C | >50 |
| CM235.c11 | CRF01_AE | >50 |
| 816367.CO2 | CRF01_AE | >50 |
| MLV | >50 | |
| Harvard | ||
| Positive neutralization | ||
| SS1196.1 | B | 30.08 |
| T271-11 | CRF02_AG | 59.08 |
| Negative neutralization | ||
| MS208.A1 | A | >100 |
| Q23.17 | A | >100 |
| MN-3 | B | >100 |
| SF162.LS | B | >100 |
| BaL.26 | B | >100 |
| 6535.3 | B | >100 |
| MW965.26 | C | >100 |
| TV1.21 | C | >100 |
| ZM109F.PB4 | C | >100 |
| DJ263.8 | CRF02_AG | >100 |
| 242-14 | CRF02_AG | >100 |
| TH023.6 | CRF01_AE | >100 |
a
IC50, 50% inhibitory concentration; UMass, University of Massachusetts Medical School; Harvard, Harvard Medical School; MLV, murine leukemia virus.