Table 1.

The effects of actin-perturbing agents on cytostome number

	% Pf with cytostomes	Odds ratio	95% confidence interval	P-value
Untreated	4.7	Referent	–	–
CD	3.6	0.75	(0.57, 0.99)	0.047
JAS	3.1	0.66	(0.50, 0.99)	0.003
CD versus JAS	–	1.14	(0.81, 1.60)	0.50

A modeled logistic regression quantifying the change in cytostome number following actin-perturbing drug treatment. PE were treated with 7 μM JAS (n=2266), 10 μM CD (n=1916), or were untreated (n=4182). Following a 3-hour incubation, PE were analyzed by electron microscopy. Data are expressed as odds ratios of the incidence of cytostomes in untreated, JAS-and CD-treated PE. Cytostomes were defined as double-membrane invaginations of the PVM/PPM that possessed electron density at their necks. Statistical significance was determined using a linear regression, where P≤0.05. n, number of PE counted. The n value for untreated PE is the result of combining the count from two separate experiments (i.e. 2266+1916). CD, cytochalasin D; JAS, jasplakinolide; Pf, Plasmodium falciparum.