Table 2.

The effects of actin-perturbing agents on CS number

	% Pf with CS	Incidence rate ratio	95% confidence interval	P-value
Untreated	26.1	Referent	–	–
CD	63.3	3.66	(3.40, 3.94)	<0.001
JAS	50.5	2.33	(2.07, 2.41)	<0.001
CD versus JAS	–	1.64	(1.53, 1.76)	<0.001

A modeled logistic regression quantifying the change in CS number following actin-perturbing drug treatment. PE were treated with 7 μM JAS (n=2266), 10 μM CD (n=1916), or were untreated (n=4182). Following a 3-hour incubation, PE were analyzed by electron microscopy. Data are expressed as an incidence rate ratio of CS in untreated, JAS- and CD-treated PE. CS are defined as double-membrane, hemoglobin-containing compartments that are not contiguous with the PVM/PPM within a single thin electron micrograph section. Statistical significance was determined using a zero-inflated Poisson regression model, where P≤0.05. n, number of PE counted. CS, cytostomal section; CD, cytochalasin D; JAS, jasplakinolide; Pf, Plasmodium falciparum.