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Hypothetical free energy profiles for activation of hlGPDH-catalyzed reduction of GA by FPO32– and S2O32– drawn for Scheme 3 to show the difference in the relative ground state (ΔΔGo = 1.1 kcal/mol) and transition state (ΔΔG‡ = 4.6 kcal/mol) binding energies. The reactions are carried out in the presence of saturating [NADH], so that cofactor binding is not a kinetically significant step.
