Figure 5.

Switch task in PWScr^m+/p+, PWScr^m+/p−, and PWScr^m+/p− mutants (A) Cartoon of the switch task. From left to right: a mouse nose pokes in the central hopper and activates a light signal. The mouse has to NP in the left hopper after 3 sec (short trial) or switch to the right hopper, and NP after 9 sec (long trial) according to the duration of light on no later than 30 sec after light off. L, light; P(S), probability of short trial; P(L), probability of long trial. (B) The error rate in the switch test, according to genotype, in the light and dark phases. Inset, histograms of total average errors for all groups of mice in light vs. dark. (C) The cumulative distribution function (CDF) of the switch latency values for PWScr^m+/p+ (n = 6), PWScr^m+/p− (n = 6), and PWScr^m−/p− (n = 5) in dark and light phases. Inset, boxplot of the mean latencies for all genotypes during dark and light phases. All graphs are presented as the means $\pm$ SEM. Significant differences are indicated as follows: ${}^{\mathrm{\ast }}P<0.05,{}^{\mathrm{\ast \ast }}P<0.01,{}^{\mathrm{\ast \ast \ast \ast }}P<\mathrm{0.001.}$