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DSBs are a substrate for homologous recombination. DSB formation is followed by a 59–39 resection of the DNA, yielding 39 single-stranded DNA (ssDNA) overhangs, after which RAD-51 is loaded, promoting homolog search and repair of the DSB as either a crossover or noncrossover. SWS-1 is predicted to assist in either the loading or stabilization of RAD-51 onto 39 overhangs. (For a detailed review of these processes in mitosis and meiosis, see Kohl and Sekelsky 2013).
