Table 1. Maximum-likelihood estimations of the Gompertz parameter values determined from published survival curves (set 2).

			Control				Mutant
Gene and allele or strain	Sex	Backgrounda	Median life span (D)	n	ln(A)	G	Median life span (D)	n	ln(A)	G	Source
AC5−/−	M+F	129/SvJ-C57BL/6	755	25	−6.74	3.46	990	13	−11.73	4.72	Yan et al. (2007)
cIGF-1tg	M	FVB/N	705	39	−3.54	1.73	880	38	−4.05	1.72	Li and Ren (2007)
IRS1−/−	F	C57BL/6	750	21	−5.11	2.73	970	14	−6.85	2.83	Selman et al. (2008)
	M		785	35	−6.84	3.50	860	13	−20.25	9.28
Klotho+46	M	C3H	785	29	−4.09	2.18	890	22	−5.61	2.53	Kurosu et al. (2005)
Klotho+48	M						1000	22	−6.24	2.55
Klotho+46	F		735	25	−4.30	2.41	840	28	−6.54	3.13
Klotho+48	F						825	29	−5.91	2.83
MTtg	M	FVB	850	55	−4.78	2.28	980	55	−4.26	1.58	Yang et al. (2006)
FGF21tg	M	C57Bl/6J	840	32	−4.56	1.94	1100	37	−7.24	2.57	Zhang et al. (2012)
S6K1−/−	F	C57BL/6	820	23	−4.43	2.15	975	29	−6.07	2.45	Selman et al. (2009)
Hcrt-UCP2	F	C57BL/6	550	31b	−2.91	2.07	660	26b	−4.06	2.42	Conti et al. (2006)
	M		720	36b	−3.24	1.75	815	53b	−4.85	2.37
MIF−/−	F	C57BL/6J-129/SvJ	740	24	−4.60	2.51	900	39	−5.01	2.17	Harper et al. (2010)
IRS1−/−	F	C57BL/6	780	16	−6.57	3.41	870	15	−4.18	1.86	Selman et al. (2011)
	M		770	37	−6.27	3.22	890	12	−5.88	2.58
GHRH−/−	M	C57BL6-129SV	610	56	−2.24	1.38	920	39	−6.18	2.67	Sun et al. (2013)
	F		660	52	−3.55	2.16	960	58	−4.67	1.90
IGF-1R+/−	F	C57BL/6J	800	38	−5.35	2.62	870	34	−6.45	2.84	Xu et al. (2014)
bIGF-1+/−	M	129/Sv×C57BL/6	830	20	−5.15	2.32	975	9	−13.98	5.70	Kappeler et al. (2008)
	F		850	22	−5.54	2.63	880	18	−6.70	2.99
Ptentg	M	C57BL6-CBA (75%:25%)	780	49	−4.77	2.56	880	32	−5.35	2.40	Ortega-Molina et al. (2012)
	F		790	63	−6.17	3.11	910	32	−7.82	3.45
Akt1+/−	F	C57BL/6	780	79	−5.40	2.85	870	80	−6.42	2.99	Nojima et al. (2013)
	M		840	101	−5.84	2.77	895	103	−5.17	2.29
mTOR∆/∆	M	129S1-C57BL/6Ncr	680	10	−5.44	3.19	830	17	−5.39	2.57	Wu et al. (2013)
	F		800	24	−3.59	1.74	960	26	−6.95	2.89
bSirt1tg	F	C57BL/6J	795	43	−5.81	2.91	930	34	−7.40	3.25	Satoh et al. (2013)
	M		855	47	−5.73	2.71	925	33	−8.35	3.53
Sirt6tg-55	M	C57BL/6J-BALB/c	865	35	−6.15	2.86	985	23	−6.41	2.54	Kanfi et al. (2012)
Sirt6tg-108	M		730	36	−4.08	2.18	790	25	−4.86	2.23
Gpx4+/−	M	C57BL/6	960	50	−6.33	2.68	1030	50	−8.81	3.57	Ran et al. (2007)
mGsta4−/−	F	C57BL/6	740	50	−4.12	2.18	840	50	−6.36	3.06	Singh et al. (2010)
hMTH1tg	M+F	C57BL/6	790	42	−7.89	4.02	910	34	−6.78	2.94	De Luca et al. (2013)
TRXtgc	M	C57BL/6	890	60	−4.15	1.73	950	60	−5.20	2.09	Pérez et al. (2011)
TgTerttgd	?	C57BL6-DBA/2	690	68	−3.91	2.24	1010	27	−7.83	3.14	Tomás-Loba et al. (2008)
UCP1tg	M+F	C57BL/6	820	53	−4.85	2.29	940	51	−6.30	2.76	Gates et al. (2007)
Dgat−/−	F	C57BL/6J	750	30	−4.34	2.30	940	30	−7.38	3.20	Streeper et al. (2012)
PKA RIIβ−/−	M	C57BL/6	900	20	−9.53	4.33	970	20	−6.68	2.79	Enns et al. (2009)
IκB-αDN	M	C57BL/6	880	23	−11.26	5.28	965	31	−9.31	3.92	Zhang et al. (2013)
BubR1tg	M+F	C57BL/6-SV129	630	60	−3.12	2.00	730	57	−3.36	1.70	Baker et al. (2013)
AT1A−/−	M	C57BL/6×129/SvEv	760	20b	−9.98	5.36	940	20	−12.57	5.30	Benigni et al. (2009)
ETA−/−	M	C57BL/6J	730	34	−3.82	1.74	920	28	−3.90	1.49	Ceylan-Isik et al. (2013)
AgRP−/−	M+F	C57BL/6J-129Sv	650	16	−5.03	3.45	710	21	−5.66	3.36	Redmann and Argyropoulos (2006)
Arf/p53tg	?	C57BL/6J	840	111	−5.12	2.47	950	25	−8.16	3.51	Matheu et al. (2007)
Mclk1+/−	M+F	129/Svj-BALB/c	764	14	−8.87	4.61	900	54	−5.2	2.35	Lapointe et al. (2009)
PAPP-A−/−	F	C57BL/6-129Sv/E	670	50	−3.48	2.00	880	38	−4.77	2.08	Conover et al. (2010)
	M		680	45	−2.71	1.45	830	40	−3.98	1.75

M, male; F, female.

^aDash denotes a mix of the indicated backgrounds; “×” denotes F₁ cross.

^bSample size approximated from survival curve.

^cCohort 2, male.

^dSp53/Sp16/SArf/TgTert^tg vs. Sp53.