Table 2. Maximum-likelihood estimates of the logistic model mortality parameters for short- and long-lived C. elegans mutant and N2 control strains.

		N2					Mutant
Gene(s)	Allele(s)	Median life span (D)	n	ln(A)	G	L	Median life span (D)	n	ln(A)	G	L	Effect on life span	Source
hsf-1	sy441	20	42	−8.00	0.342	0.282	12	42	−7.98	0.633	1.441	0.600	Hajdu-Cronin et al. (2004)
gas-1	fc21	19	100	−8.61	0.426	1.358	12	100	−7.87	0.668	2.442	0.632	Suthammarak et al. (2013)
skn-1	zu129	15	75	−6.49	0.371	1.535	10	75	−24.72	3.093	11.184	0.667	An and Blackwell (2003)
mev-1	kn1	19	100	−8.61	0.426	1.358	13	100	−5.35	0.291	0.226	0.684	Suthammarak et al. (2013)
jnk-1	gk7	16	386	−8.90	0.537	1.997	12	333	−14.39	1.270	4.723	0.750	Ezekowitz (2014)
daf-16	m26	20	19	−7.54	0.345	1.186	15	37	−14.57	0.995	3.603	0.750	Kenyon et al. (1993)
jkk-1	km2	16	386	−8.90	0.537	1.997	13	189	−13.51	1.063	2.651	0.813	Ezekowitz (2014)
sir-2.1	ok434	19	70	−5.63	0.188	0.000	16	94	−7.28	0.358	0.014	0.842	Berdichevsky et al. (2006)
clk-2	qm37	18	50a	−14.95	0.839	2.666	18	50a	−14.93	0.945	6.160	1.000	Van Raamsdonk et al. (2010)
ctbp-1	ok498	19	254	−7.35	0.325	0.659	22	236	−8.52	0.330	0.492	1.158	Chen et al. (2009)
cep-1	gk138	17	115	−9.33	0.493	0.856	20	116	−10.08	0.496	2.446	1.176	Tavernarakis et al. (2008)
age-1	hx546	34	50	−7.18	0.142	0.000	42	50	−6.94	0.110	0.000	1.235	Yanase et al. (2002)
clk-5	qm152	18	50a	−14.95	0.839	2.666	24	50a	−14.83	0.585	2.479	1.333	Van Raamsdonk et al. (2010)
clk-8	qm162	18	50a	−14.95	0.839	2.666	24	50a	−8.57	0.325	1.383	1.333	Van Raamsdonk et al. (2010)
daf-19	m86	18	347	−8.45	0.475	2.471	24	35	−6.96	0.203	0.258	1.333	Apfeld and Kenyon (1999)
mec-8	e398	18	347	−8.45	0.475	2.471	24	46	−8.08	0.219	0.996	1.333	Apfeld and Kenyon (1999)
egl-30	ad806	18	50	−19.95	1.502	9.977	25	62	−6.12	0.146	0.000	1.389	Ch’ng et al. (2008)
arr-1	ok401	12	180	−5.38	0.331	0.457	17	210	−4.83	0.176	0.075	1.417	Palmitessa and Benovic (2010)
cdc-48.1; atx-3	tm544;gk193	19	312	−7.24	0.317	0.704	27	222	−6.95	0.184	0.382	1.421	Kuhlbrodt et al. (2011)
clk-3	qm38	18	50a	−14.95	0.839	2.666	26	50a	−10.41	0.341	0.884	1.444	Van Raamsdonk et al. (2010)
clk-1	qm30	18	309	−8.91	0.451	0.982	26	112	−21.52	0.903	7.037	1.444	Van Raamsdonk and Hekimi (2009)
che-13	e1805	18	347	−8.45	0.475	2.471	26	36	−5.89	0.142	0.206	1.444	Apfeld and Kenyon (1999)
che-2	e1033	18	347	−8.45	0.475	2.471	26	33	−25.00	1.560	19.645	1.444	Apfeld and Kenyon (1999)
daf-6	e1377	18	347	−8.45	0.475	2.471	26	75	−5.83	0.138	0.193	1.444	Apfeld and Kenyon (1999)
osm-1	p808	18	347	−8.45	0.475	2.471	26	17	−7.21	0.195	0.000	1.444	Apfeld and Kenyon (1999)
daf-4	e1364	15	60	−13.21	0.851	1.699	22	71	−11.14	0.479	1.927	1.467	Shaw et al. (2007)
nuo-6	qm200	22	150	−12.51	0.535	0.818	33	120	−10.38	0.288	1.743	1.500	Yang and Hekimi (2010)
clk-10	qm169	18	50a	−14.95	0.839	2.666	28	50a	−6.66	0.154	0.292	1.556	Van Raamsdonk et al. (2010)
clk-6	qm158	18	50a	−14.95	0.839	2.666	28	50a	−11.78	0.398	2.622	1.556	Van Raamsdonk et al. (2010)
clk-9	qm164	18	50a	−14.95	0.839	2.666	28	50a	−10.79	0.354	1.282	1.556	Van Raamsdonk et al. (2010)
sod-2	ok1030	18	309	−8.91	0.451	0.982	28	373	−8.44	0.255	0.805	1.556	Van Raamsdonk and Hekimi (2009)
che-11	e1810	18	347	−8.45	0.475	2.471	28	27	−6.02	0.126	0.000	1.556	Apfeld and Kenyon (1999)
daf-10	e1387	18	347	−8.45	0.475	2.471	29	30	−8.89	0.252	0.877	1.611	Apfeld and Kenyon (1999)
osm-6	p811	18	347	−8.45	0.475	2.471	30	30	−8.53	0.220	0.000	1.667	Apfeld and Kenyon (1999)
clk-7	qm159	18	50a	−14.95	0.839	2.666	32	50a	−8.03	0.212	1.109	1.778	Van Raamsdonk et al. (2010)
osm-3	p802	18	347	−8.45	0.475	2.471	32	133	−7.86	0.195	0.556	1.778	Apfeld and Kenyon (1999)
egl-3	nr2090	18	46	−11.13	0.704	4.043	32	63	−7.27	0.163	0.452	1.778	Ch’ng et al. (2008)
clk-4	qm151	18	50a	−14.95	0.839	2.666	34	50a	−5.99	0.095	0.033	1.889	Van Raamsdonk et al. (2010)
eat-2	ad1116	18	309	−8.91	0.451	0.982	35	156	−13.18	0.366	2.838	1.944	Van Raamsdonk and Hekimi (2009)
tax-4	p678	18	347	−8.45	0.475	2.471	37	105	−8.90	0.186	0.299	2.056	Apfeld and Kenyon (1999)
che-3	p801	18	347	−8.45	0.475	2.471	40	31	−9.17	0.192	0.509	2.222	Apfeld and Kenyon (1999)
isp-1	qm150	18	309	−8.91	0.451	0.982	42	114	−6.66	0.097	0.487	2.333	Van Raamsdonk and Hekimi (2009)
clk-1; sod-2	ok1030	18	309	−8.91	0.451	0.982	44	147	−9.36	0.169	0.687	2.444	Van Raamsdonk and Hekimi (2009)
osm-5	p813	18	347	−8.45	0.475	2.471	44	46	−6.74	0.092	0.000	2.444	Apfeld and Kenyon (1999)
daf-2; clk-9	e1370; qm164	21	200b	−7.72	0.303	0.265	59	200b	−8.43	0.130	0.429	2.810	Van Raamsdonk et al. (2010)
daf-2; clk-2	e1370; qm37	15	200b	−10.90	0.720	2.747	48	200b	−6.08	0.055	0.313	3.200	Van Raamsdonk et al. (2010)
daf-2	e1370	18	309	−8.91	0.451	0.982	63	168	−7.38	0.074	0.000	3.500	Van Raamsdonk and Hekimi (2009)

Note that some mutant strains were compared to the same N2.

^aTwenty worms per plate were examined with three trials per strain.

^bSum of at least three independent trials and an initial number of 80 worms per strain per trial.