Table 1.
Subject characteristics (n=69)
| Characteristic | N (%) |
|---|---|
| Age, years | |
| Mean±SD | 16.0±2.9 |
| 0–6 | 0 (0.0) |
| 7–11 | 5 (7.3) |
| 12–17 | 53 (76.8) |
| 18–24 | 11 (15.9) |
| Female sex | 26 (37.7) |
| Race/ethnicity (n=4 unknown) | |
| White | 38 (58.5) |
| Asian | 9 (13.8) |
| Black | 9 (13.8) |
| Hispanic | 8 (12.3) |
| Other | 1 ( 1.5) |
| Liver disease diagnosis | |
| Autoimmune hepatitis (includes drug-induced + PSC overlap) | 18 (26.1) |
| NAFLD (n=10 NASH) | 14 (20.3) |
| Viral hepatitis | 13 (18.8) |
| Wilson’s disease/Alpha 1 antitrypsin deficiency | 3 ( 4.5) |
| Cellular rejection | 1 ( 1.4) |
| Cholestasis (includes PFIC) | 1 ( 1.4) |
| Other1 | 19 (27.5) |
| Anthropometry | |
| BMI (kg/m2) | 22.6 (19.6, 29.2) |
| BMI percentile (among 63 subjects <20y) | 74.9 (37.8, 97.4) |
| BMI z-score (among 63 subjects <20y) | 0.67 (−0.31, 1.95) |
| Blood tests nearest to time of CAP | |
| ALT, U/L (n=62) | 85 (43, 180) |
| AST, U/L (n=56) | 47 (34, 111) |
| GGTP, U/L (n=49) | 83 (37, 154) |
| Steatosis | 23 (33.3) |
| Mild | 7 (30.4) |
| Moderate | 4 (17.4) |
| Marked | 12 (52.2) |
1
7 with PSC, 5 with chronic hepatitis of unknown etiology, 2 with lysosomal acid lipase deficiency, 1 routine liver biopsy at the time of bariatric surgery, 1 with diabetes associated glycogenic hepatopathy, 1 with veno-occlusive disease, 1 with nodular regenerative hyperplasia, and 1 with severe combined immunodeficiency s/p stem cell transplant