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. 2016 Nov 11;11(11):e0166333. doi: 10.1371/journal.pone.0166333

Table 6. Nutritional status and risk of incident tuberculosis (TB) disease stratified by age.

All secondary TB cases Microbiologically confirmed secondary pulmonary TB cases
Age Categories Overweight vs. Normal Weight Multivariate HRa (95% CI) N = 11,363 p value Overweight vs. Normal Weight Multivariate HRa (95% CI) N = 11,256 p value
<5 years 0.73 (0.32–1.63) 0.44 NAb
5 to 11 years 1.16 (0.55–2.45) 0.70 0.97 (0.37–2.58) 0.96
12 to 19 years 0.23 (0.06–0.93) 0.04 0.14 (0.02–1.04) 0.05
20 to 49 years 0.47 (0.33–0.67) <0.001 0.51 (0.35–0.75) 0.001
≥50 years 0.36 (0.20–0.67) 0.001 0.37 (0.19–0.70) 0.003

HR, Hazard Ratio.

a Adjusted for age, sex, nutritional status, comorbid disease (heart disease, high blood pressure, asthma, kidney disease, use of steroids or chemotherapy or immunosuppressant, any other self-reported chronic illness), BCG scar, isoniazid preventive therapy, heavy alcohol consumption, tobacco use, socio-economic status, TB history, index smear status and index cavitary disease.

b None of the overweight study participants in this age group developed microbiologically confirmed pulmonary TB disease.