Table 8. Sensitivity analysis of baseline characteristics associated with incident tuberculosis (TB) disease diagnosed at least 90 days after index case enrollment.
| Person-years | Univariate HR (95% CI) | p value | Multivariate HR (95% CI) | p value | |
|---|---|---|---|---|---|
| Household Contacts Characteristics | |||||
| Age Categories | 11,995 | ||||
| < 5 years | 0.78 (0.42–1.46) | 0.44 | 0.86 (0.41–1.83) | 0.70 | |
| 5 to 11 years | 0.75 (0.41–1.37) | 0.34 | 0.90 (0.45–1.93) | 0.78 | |
| 12 to 19 years | 2.21 (1.36–3.58) | 0.001 | 2.14 (1.18–3.85) | 0.01 | |
| 20 to 49 years | 1.07 (0.67–1.70) | 0.77 | 1.29 (0.77–2.17) | 0.33 | |
| ≥50 years | Reference | Reference | |||
| Male | 11,995 | 0.95 (0.71–1.27) | 0.71 | 0.95 (0.70–1.30) | 0.75 |
| Nutritional Status | 11,995 | ||||
| Underweight | 1.05 (0.38–2.87) | 0.93 | 1.31 (0.47–3.63) | 0.60 | |
| Overweight | 0.44 (0.31–0.62) | <0.001 | 0.41 (0.28–0.62) | <0.001 | |
| Normal | Reference | Reference | |||
| Comorbid Diseasea | 11,993 | 1.28 (0.92–1.80) | 0.15 | 1.41 (0.97–2.03) | 0.07 |
| BCG Scar | 11,993 | 0.60 (0.42–0.85) | 0.004 | 0.65 (0.44–0.95) | 0.03 |
| Isoniazid Preventive Therapy | 11,989 | 0.77 (0.53–1.11) | 0.16 | NAb | |
| Heavy Alcohol Use | 11,763 | 0.97 (0.51–1.87) | 0.94 | 0.75 (0.36–1.59) | 0.46 |
| Tobacco Use | 11,871 | 0.92 (0.49–1.71) | 0.79 | 1.01 (0.51–2.00) | 0.97 |
| HIV Positive | 11,851 | 3.15 (0.75–13.28) | 0.12 | 2.51 (0.56–11.22) | 0.23 |
| Socioeconomic Status | 11,684 | ||||
| Middle | Reference | Reference | |||
| Low | 1.47 (1.04–2.07) | 0.03 | 1.52 (1.07–2.17) | 0.02 | |
| High | 1.01 (0.65–1.56) | 0.97 | 1.13 (0.72–1.75) | 0.60 | |
| Self-Reported Diabetes Mellitus | 11,910 | 2.06 (0.90–4.72) | 0.09 | 2.92 (1.22–7.01) | 0.02 |
| History of TB | 11,976 | 2.66 (1.80–3.92) | <0.001 | 2.71 (1.78–4.13) | <0.001 |
| Index Cases Characteristics | |||||
| HIV Positive | 11,873 | 0.61 (0.21–1.82) | 0.38 | NA | |
| Smear Positive | 11,988 | 1.71 (1.10–2.66) | 0.02 | 1.74 (1.10–2.76) | 0.02 |
| Cavitary Disease | 11,826 | 1.26 (0.90–1.75) | 0.18 | 1.18 (0.84–1.67) | 0.34 |
| Tobacco use | 11,756 | 0.83 (0.29–2.38) | 0.72 | NA | |
| Heavy Alcohol Use | 11,512 | 1.13 (0.69–1.88) | 0.62 | NA | |
BCG, Bacillus Calmette–Guérin; HR, Hazard Ratio.a Comorbid disease includes any of the following: heart disease, high blood pressure, asthma, kidney disease, use of steroids or chemotherapy or immunosuppressant, any other self-reported chronic illness.
b Variable identified as a time-varying covariate.