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. 2016 Nov 11;11(11):e0166423. doi: 10.1371/journal.pone.0166423

Fig 6. 968 and DHA cooperatively increase intracellular ROS leading to enhanced cytotoxicity in LM3 cells.

Fig 6

a & b, The intracellular ROS level was assessed after cells were treated with 968 and/or DHA for 12 or 24 h. The results are shown as the means ± SD of three independent experiments. *P < 0.05 and **P < 0.01 compared with the intracellular ROS level in cells treated with 968 or DHA only. Peak values associated with treatment for 12 h (left) and 24 h (right) are representative of three independent experiments. c, Cells were pretreated with NAC (3 mM) for 2 h and then treated with 968 and DHA for 48 h. The results are shown as the means ± SD of three independent experiments. ** P < 0.01 compared with cells without NAC pretreatment (UT group).