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. 2016 Nov 11;12(11):e1005195. doi: 10.1371/journal.pcbi.1005195

Fig 11. Two NetPocos associated with CAD.

Fig 11

Two NetPocos associated with Coronary Artery Disease (CAD). These NetPocos are consistently selected by L1 regularized logistic regression in the final model for risk prediction. The circle nodes represent proteins and rectangular nodes represent SNPs. Red dashed lines represent the eQTL association between a SNP and a gene, purple lines indicate that a SNP is in the ROI of the respective gene, and the blue edges represent a protein-protein interaction (PPI) between the products of respective genes. The genes that are previously reported to be associated with CAD are highlighted in gold. (a) A NetPoco enriched in cardia muscle tissue regeneration (p-value = 0.0003) and activation of MAPKK activity (p-value = 0.02), (b) a NetPoco enriched in positive regulation of insulin-like growth factor receptor signaling pathway (p-value = 0.0006).