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. 2016 Nov 11;12(11):e1005195. doi: 10.1371/journal.pcbi.1005195

Fig 12. Two NetPocos associated with BD.

Fig 12

Two NetPocos associated with Bipolar Disorder (BD). These NetPocos are consistently selected by L1 regularized logistic regression in the final model for risk prediction. The circle nodes represent proteins and rectangular nodes represent SNPs. Red dashed lines represent the eQTL association between a SNP and a gene, purple lines indicate that a SNP is in the ROI of the respective gene, and the blue edges represent a protein-protein interaction (PPI) between the products of respective genes. The genes that are previously reported to be associated with CAD are highlighted in gold. (a) A NetPoco enriched in regulation of dopamin metabolic process which plays a central role in bipolar disorder (p-value = 8.67e-6), (b) a NetPoco enriched in regulation of neurotrasmitter secretion and insulin receptor signaling pathway (p-value = 0.0007).