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. 2016 Nov 11;12(11):e1006423. doi: 10.1371/journal.pgen.1006423

Fig 1. Genes with heritable expression in DGN whole blood are more tolerant to loss of function mutations.

Fig 1

The distribution of the probability of being loss-of-function intolerant (pLI) for each gene (from the Exome Aggregation Consortium [32]) dichotomized by local heritability estimates. The Kruskal-Wallis rank sum test revealed a significant difference in the pLI of heritability groups (χ2 = 234, P < 10−52). More heritable genes (h2 > 0.1 in blue) have lower pLI metrics and are thus more tolerant to mutation than genes with lower h2.