Fig 6. Measure of uniformity of the posterior probability of active regulation vs. cross-tissue heritability.
Uniformity was computed using the posterior probability of a gene being actively regulated in a tissue, PPA, from the Flutre et al. [33] multi-tissue eQTL analysis. (A) Representative examples showing that genes with PPA concentrated in one tissue were assigned small values of the uniformity measure whereas genes with PPA uniformly distributed across tissues were assigned high value of uniformity measure. See Methods for the entropy-based definition of uniformity. (B) This panel shows the distribution of heritability of the cross-tissue component vs. a measure of uniformity of genetic regulation across tissues. The Kruskal-Wallis rank sum test revealed a significant difference in the cross-tissue h2 of uniformity groups (χ2 = 31.4, P < 10−6).