Table 1. Estimates of unconstrained local h2 across genes within tissues.
| tissue | n | mean h2 (SE) | % FDR<0.1 | num FDR<0.1 | num expressed |
|---|---|---|---|---|---|
| DGN Whole Blood | 922 | 0.149 (0.0039) | 58.8 | 7474 | 12719 |
| Cross-tissue | 450 | 0.062 (0.017) | 20.2 | 2995 | 14861 |
| Adipose—Subcutaneous | 298 | 0.038 (0.028) | 18.8 | 2666 | 14205 |
| Adrenal Gland | 126 | 0.043 (0.018) | 17.5 | 2479 | 14150 |
| Artery—Aorta | 198 | 0.042 (0.024) | 17.2 | 2385 | 13844 |
| Artery—Coronary | 119 | 0.037 (0.048) | 16.5 | 2326 | 14127 |
| Artery—Tibial | 285 | 0.042 (0.02) | 18.4 | 2489 | 13504 |
| Brain—Anterior cingulate cortex (BA24) | 72 | 0.028 (0.036) | 15.4 | 2235 | 14515 |
| Brain—Caudate (basal ganglia) | 100 | 0.037 (0.047) | 17.2 | 2521 | 14632 |
| Brain—Cerebellar Hemisphere | 89 | 0.049 (0.068) | 16.0 | 2294 | 14295 |
| Brain—Cerebellum | 103 | 0.050 (0.06) | 18.3 | 2646 | 14491 |
| Brain—Cortex | 96 | 0.045 (0.057) | 17.7 | 2593 | 14689 |
| Brain—Frontal Cortex (BA9) | 92 | 0.038 (0.077) | 16.6 | 2416 | 14554 |
| Brain—Hippocampus | 81 | 0.037 (0.05) | 16.4 | 2376 | 14513 |
| Brain—Hypothalamus | 81 | 0.017 (0.043) | 15.2 | 2238 | 14759 |
| Brain—Nucleus accumbens (basal ganglia) | 93 | 0.029 (0.04) | 17.1 | 2498 | 14601 |
| Brain—Putamen (basal ganglia) | 82 | 0.032 (0.064) | 17.3 | 2495 | 14404 |
| Breast—Mammary Tissue | 183 | 0.029 (0.037) | 17.0 | 2496 | 14700 |
| Cells—EBV-transformed lymphocytes | 115 | 0.058 (0.1) | 16.6 | 2066 | 12454 |
| Cells—Transformed fibroblasts | 272 | 0.051 (0.031) | 20.0 | 2552 | 12756 |
| Colon—Sigmoid | 124 | 0.033 (0.019) | 16.0 | 2298 | 14321 |
| Colon—Transverse | 170 | 0.036 (0.058) | 16.3 | 2398 | 14676 |
| Esophagus—Gastroesophageal Junction | 127 | 0.032 (0.039) | 16.1 | 2270 | 14125 |
| Esophagus—Mucosa | 242 | 0.042 (0.03) | 17.1 | 2432 | 14239 |
| Esophagus—Muscularis | 219 | 0.039 (0.015) | 17.7 | 2493 | 14047 |
| Heart—Atrial Appendage | 159 | 0.042 (0.03) | 16.8 | 2327 | 13892 |
| Heart—Left Ventricle | 190 | 0.034 (0.034) | 16.5 | 2203 | 13321 |
| Liver | 98 | 0.033 (0.062) | 16.5 | 2230 | 13553 |
| Lung | 279 | 0.032 (0.034) | 17.0 | 2509 | 14775 |
| Muscle—Skeletal | 361 | 0.033 (0.03) | 17.9 | 2301 | 12833 |
| Nerve—Tibial | 256 | 0.052 (0.087) | 20.6 | 2992 | 14510 |
| Ovary | 85 | 0.037 (0.094) | 17.2 | 2418 | 14094 |
| Pancreas | 150 | 0.047 (0.024) | 17.2 | 2398 | 13941 |
| Pituitary | 87 | 0.038 (0.055) | 16.6 | 2527 | 15183 |
| Skin—Not Sun Exposed (Suprapubic) | 196 | 0.041 (0.034) | 17.0 | 2490 | 14642 |
| Skin—Sun Exposed (Lower leg) | 303 | 0.039 (0.016) | 18.4 | 2687 | 14625 |
| Small Intestine—Terminal Ileum | 77 | 0.036 (0.053) | 17.4 | 2591 | 14860 |
| Spleen | 89 | 0.059 (0.061) | 17.0 | 2451 | 14449 |
| Stomach | 171 | 0.032 (0.025) | 16.1 | 2338 | 14531 |
| Testis | 157 | 0.054 (0.044) | 17.8 | 3009 | 16936 |
| Thyroid | 279 | 0.044 (0.066) | 19.4 | 2838 | 14642 |
| Whole Blood | 339 | 0.033 (0.023) | 18.6 | 2260 | 12160 |
Except for DGN Whole Blood, all tissues are from the GTEx Project. Cross-tissue uses derived expression levels from our orthogonal tissue decomposition (OTD) of GTEx data. Mean heritability (h2) is calculated across genes for each tissue. The standard error (SE) is estimated from the h2 estimates obtained when the expression sample labels are shuffled 100 times. The percentage (%) and number (num) of genes with significant h2 estimates (FDR < 0.1) in each tissue are reported. The number of genes in each tissue with mean RPKM > 0.1 (num expressed) is also reported.