Fig. 7. Proposed model of chromatin reassembly during or after replication.

The original histones are nearly quantitatively recovered on leading strand (after survival and translocation) and lagging strand (after translocation). Three pathways of nucleosome reformation after replication are proposed: (i) original histone octamers survive at the original positions on DNA, (ii) original histone octamers are transferred within the 400-bp region upstream of the replisome, or (iii) de novo histone assembly after replication.