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. 2016 Oct 26;5:e20930. doi: 10.7554/eLife.20930

Table 4.

The γB6 mutant V562D disrupts the EC6-dependent cis interaction in solution. Sedimentation equilibrium analytical ultracentrifugation results for wild-type PcdhγB6EC1–6 and the γB6EC1–6 V562D (γB2 numbering) EC6 mutant.

DOI: http://dx.doi.org/10.7554/eLife.20930.033

Pcdh fragment

Oligomeric state

Dissociation constant (μM)

γB6EC1–6

Tetramer

3.4/2.7*

γB6EC1–6 V562D

Dimer

22.3 ± 0.793

*KDs of monomer-to-dimer / dimer-to-tetramer transitions from fitting the data to a tetramer model. Related to Figure 6 and Figure 6—figure supplement 1.