Table 1.
Comparison of clinical characteristics between poor responders and responders
| Characteristics | Total (n=166) |
Poor responders (n=109) |
Responders (n=57) |
P-value |
|---|---|---|---|---|
| Age, years | 64 (56–70) | 62 (54–70) | 64 (59–70) | 0.202 |
| Sex, male | 113 (68.1) | 68 (62.4) | 45 (78.9) | 0.03 |
| Current smoker or ex-smoker | 93/162 (57.4) | 54/106 (50.9) | 39/56 (69.6) | 0.022 |
| Body mass index, kg/m2 | 22.8 (20.7–25.4) | 22.7 (20.5–25.2) | 23.6 (21.3–25.7) | 0.24 |
| Body mass index ≥25 kg/m2 | 51 (30.7) | 30 (27.5) | 21 (36.8) | 0.217 |
| Previous pulmonary tuberculosis | 74 (44.6) | 51 (46.8) | 23 (40.4) | 0.428 |
| Coexisting pulmonary comorbidities | ||||
| Bronchial asthma | 28 (16.9) | 16 (14.7) | 12 (21.1) | 0.298 |
| NTM lung disease | 13 (7.8) | 11 (10.1) | 2 (3.5) | 0.222 |
| Chronic aspergillosis | 5 (3) | 2 (1.8) | 3 (5.3) | 0.34 |
| Extrapulmonary comorbidities | ||||
| Hypertension | 51 (30.7) | 33 (30.3) | 18 (31.6) | 0.863 |
| Malignant disease | 23 (13.9) | 13 (11.9) | 10 (17.5) | 0.32 |
| Diabetes mellitus | 21 (12.7) | 14 (12.8) | 7 (12.3) | 0.917 |
| Chronic kidney disease | 7 (4.2) | 4 (3.7) | 3 (5.3) | 0.692 |
| Cerebrovascular disease | 7 (4.2) | 3 (2.8) | 4 (7) | 0.234 |
| Baseline pulmonary function test | ||||
| FVC, L | 2.8 (2.1–3.3) | 2.6 (2.1–3.4) | 2.9 (2.3–3.2) | 0.526 |
| FVC, % predicted | 70.5 (60.0–80.0) | 73.0 (60.5–80.5) | 69.0 (60.0–77.5) | 0.276 |
| FEV1, L | 1.4 (1.1–1.8) | 1.5 (1.1–1.9) | 1.4 (1.1–1.7) | 0.288 |
| FEV1, % predicted | 50.0 (39.0–61.0) | 51.0 (39.5–63.0) | 46.0 (38.0–55.5) | 0.065 |
| FEV1/FVC, % | 53.7 (45.6–60.9) | 55 (47–62.4) | 50.5 (43.5–58) | 0.011 |
| Positive bronchodilator response | 42 (25.3) | 20 (18.3) | 22 (38.6) | 0.004 |
Note: Data presented as n (%) or medians and interquartile ranges.
Abbreviations: NTM, nontuberculous mycobacteria; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second.