Table 1.

The WASOG organ-assessment tool for neurosarcoidosis

WASOG organ-assessment tool126
Highly probable
Clinical syndrome consistent with granulomatous inflammation of the meninges, brain, ventricular (CSF) system, cranial nerves, pituitary gland, spinal cord, cerebral vasculature, or nerve roots plus
An abnormal MRI characteristic of neurosarcoidosis, defined as exhibiting abnormal enhancement following the administration of gadolinium or a CSF exam demonstrating inflammation
At least probable
Isolated facial palsy, negative MRI
Clinical syndrome consistent with granulomatous inflammation of the meninges, brain, ventricular (CSF) system, cranial nerves, pituitary gland, spinal cord, cerebral vasculature, or nerve roots, but without characteristic cMRI or CSF findings
Possible
Seizures, negative MRI
Cognitive decline, negative MRI
No consensus
Peripheral neuropathy involving large fibers (including axonal and demyelinating polyneuropathies and multiple mononeuropathies)
Cranial nerve palsies other than VII, negative MRI
Pleocytosis in the CSF
Low CSF glucose

Notes: Adapted from Judson MA, Costabel U, Drent M, et al. The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool. Sarcoidosis Vasc Diffuse Lung Dis. 2014;31(1):19–27.126

Abbreviations: CSF, cerebrospinal fluid; cMRI, cranial magnetic resonance imaging; WASOG, World Association of Sarcoidosis and Other Granulomatous Diseases.