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(A) H&E staining of major organs and (B) TUNEL analysis of tumor sections harvested from tumor-bearing mice on the 12th day after they are treated with saline, DOX-Sol, HA-VES4/DOX, HA-VES7/DOX, and HA-VES12/DOX. (White arrows indicate histological damage).
Abbreviations: DOX, doxorubicin; HA, hyaluronic acid; H&E, hematoxylin and eosin; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; VES, vitamin E succinate.
