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. Author manuscript; available in PMC: 2017 Feb 10.
Published in final edited form as: Cell Host Microbe. 2016 Feb 10;19(2):240–253. doi: 10.1016/j.chom.2016.01.008

Figure 7. Origin and pathophysiological consequences of age-related gastric metaplasia.

Figure 7

Age-related increase of JAK/Stat activity, induced by increased cytokines from the gut and/or fat body, causes metaplasia in the CCR. This results in pH imbalance, promoting commensal dysbiosis, inflammation and dysplasia in the old intestine.