. Author manuscript; available in PMC: 2017 Dec 1.

Published in final edited form as: Am J Surg Pathol. 2016 Dec;40(12):e94–e102. doi: 10.1097/PAS.0000000000000749

Table 2.

Accuracy/reproducibility of select SEER pathology diagnoses in comparison to a standard review

Organ site and/or cancer	Pathology standard	Accuracy/reproducibility
Kidney/renal cell carcinoma³⁵ Clear cell carcinoma Papillary carcinoma Chromophobe carcinoma	1 pathologist	Agreement=78.2% (kappa=0.55: Moderate) Sensitivity/Specificity=79.1/88.1% Sensitivity/Specificity=73.5/97.5% Sensitivity/Specificity=72.4/97.6%
Lung³⁶ Squamous cell carcinoma Small cell carcinoma Large cell carcinoma Adenocarcinoma	2 pathologists	Agreement=91% Sensitivity/Specificity=70.9/96.2% Agreement=98%. Sensitivity/Specificity=94.1/98.8% Agreement=87.9%. Sensitivity/Specificity=21.9/93.7% Agreement=82.9%. Sensitivity/Specificity=80.8/84.4%
Hodgkin’s disease³⁷	1 pathologist	Agreement=68% (kappa=0.66: Substantial)
Ovarian carcinoma³⁸ 3 tier grade Serous carcinoma – (2 tier grade) Mucinous carcinoma Endometrioid carcinoma Clear cell carcinoma	1 pathologist	Agreement=57% (kappa=0.21: Fair) – Agreement=64% (kappa=0.10: Slight) Agreement=44% (kappa=0.26: Fair) Agreement=46% (kappa=0.26: Fair) Agreement=24% (kappa=0.00: Chance)