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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Am J Surg Pathol. 2016 Dec;40(12):1579–1590. doi: 10.1097/PAS.0000000000000744

Table 2.

Summary of driver mutation types

Driver mutation Total (%) Type N (%)
KRAS 129 (27) G12C 57 (44)
G12V 22 (17)
G12D 15 (12)
G12A 14 (11)
G12F 2 (2)
G12R 1 (1)
G12S 1 (1)
G13C 8 (6)
G13D 1 (1)
Q61H 4 (3)
Q61L 2 (2)
Q61R 1 (1)
A146T 1 (1)
EGFR 86 (18) L858R 42 (49)
Exon 19 del. 39 (45)
L861Q 2 (2)
S768I 2 (2)
G719A 1 (1)
BRAF 8 (2) V600E 6 (75)
D594G 2 (25)
PIK3CA* 8 (2) E542K 4 (50)
C420K 1 (13)
E545K 1 (13)
H1047R 1 (13)
R88Q 1 (13)
NRAS 4 (1) Q61L 2 (50)
Q61K 1 (25)
G31R 1 (25)
AKT1 1 (0.2) E17K 1 (100)
*

Among PIK3CA mutated tumors, 2 coexisted with KRAS mutation and 2 with EGFR mutation.

EGFR, epidermal growth factor receptor