Table 6.
Multivariate analyses
| (A) For overall survival | ||||
|---|---|---|---|---|
|
| ||||
| Variables | HR | 95% CI | P | |
| Age, years | >65 vs. ≤65 | 1.78 | 1.24–2.55 | 0.002 |
| Sex | male vs. female | 1.73 | 1.26–2.36 | 0.001 |
| Surgery | limited resection vs. lobectomy | 2.31 | 1.62–3.29 | < 0.001 |
| Pathologic stage | IB vs. IA | 1.40 | 1.02–1.93 | 0.039 |
| Vascular invasion | positive vs. negative | 1.45 | 1.04–2.01 | 0.027 |
| KRAS mutation | mutant vs. wild-type | 1.87 | 1.36–2.58 | < 0.001 |
| (B) For disease recurrence | ||||
|---|---|---|---|---|
|
| ||||
| Variables | HR | 95% CI | P | |
| Sex | male vs. female | 1.63 | 0.98–2.71 | 0.058 |
| Smoking | ever vs. never | 1.31 | 0.61–2.81 | 0.49 |
| Necrosis | present vs. absent | 1.27 | 1.14–1.41 | < 0.001 |
| Pathologic stage | IB vs. IA | 1.81 | 1.1–2.97 | 0.019 |
| KRAS mutation | mutant vs. wild-type in solid predominant tumors | 4.73 | 1.41–15.9 | 0.012 |
| mutant vs. wild-type in non-solid predominant tumors | 0.91 | 0.49–1.66 | 0.75 | |
Significant P-values are shown in bold.
HR, hazard ratio; CI, confidence interval