. Author manuscript; available in PMC: 2019 Nov 1.

Published in final edited form as: Prostaglandins Leukot Essent Fatty Acids. 2016 May 11;138:71–80. doi: 10.1016/j.plefa.2016.05.004

Table 2.

Plasma oxylipin concentrations (pmol/ml plasma)

	TOTAL			UNESTERIFIED

Compound	0.4% Group Median (IQR)	5.2% Group Median (IQR)	10.5% Group Median (IQR)	0.4% Group Median (IQR)	5.2% Group Median (IQR)	10.5% Group Median (IQR)
n-6 Derivatives LA
9-HODE	54.1 (35.9, 121.5)	46.5 (25.5, 115.9)	81.0 (54.7, 102.9)	43.2 (27.9, 74.8)	28.0 (20.0, 45.3)	37.6 (32.2, 58.8)
13-HODE	86.0 (55.3, 168.6)	68.1 (40.1, 180.6)	106.8 (80.5, 131.9)	76.1 (51.4, 119.8)	49.5 (39.1, 77.5)	74.6 (60.0, 106.5)
Total HODE	147.5 (91.2, 282.7)	114.6 (65.5, 296.6)	188.4 (133.8, 234.1)	119.3 (79.3, 194.5)	76.3 (60.2, 122.8)	114.7 (92.5, 162.5)
9-oxo-ODE	251.9 (108.7, 353.1)	265.4 (204.1, 329.4)	498.5 (123.1, 770.0)	128.3 (80.7, 222.5)	200.5 (109.0, 357.0)	265.6 (151.3, 362.3)
13-oxo-ODE	19.8 (11.8, 34.7)	27.9 (18.6, 46.5)	58.9 (6.2, 102.5)	14.2 (6.8, 23.2)	19.1 (9.8, 60.8)	13.4 (9.3, 19.2)
9(10)-EpOME	120.1 (59.5, 391.7)	208.4 (114.1, 310.7)	196.2 (125.4, 499.5)	14.2 (9.2, 25.2)^a	93.5 (49.5, 185.0)^b	175.0 (68.0, 520.0)^b
12(13)-EpOME	600.5 (153.2, 1,255.0)	1,037.5 (364.7, 2,060.0)	583.8 (382.8, 2,765.3)	14.2 (12.9, 29.9)^a	82.0 (39.6, 182.8)^b	169.0 (73.0, 529.0)^b
Total EpOME	848.6 (212.7, 1,518.6)	1,321.1 (478.8, 2,295.4)	740.3 (547.8, 3,264.8)	27.9 (22.5, 55.1)^a	175.4 (88.2, 367.8)^b	346.3 (141.0, 1,059.3)^b
9,10-DiHOME	4.1 (3.4, 4.8)^a	16.6 (11.5, 21.0)^b	32.3 (21.5, 45.6)^b	2.8 (2.2, 4.5)^a	8.1 (7.1, 8.7)^ab	16.1 (14.6, 24.1)^b
12,13-DiHOME	5.7 (4.8, 6.2)^a	13.3 (6.9, 15.4)^b	18.3 (12.0, 26.5)^b	3.5 (2.1, 3.9)^a	5.9 (5.5, 8.2)^b	8.7 (7.9, 13.1)^b
Total DiHOME	9.2 (8.8, 10.2)^a	31.3 (18.3, 35.3)^b	52.7 (33.4, 69.7)^b	5.8 (4.8, 8.3)^a	13.9 (13.1, 16.4)^ab	24.0 (22.3, 37.2)^b
9,10,13-TriHOME				2.0 (1.2, 2.5)	2.1 (1.0, 3.3)	4.0 (1.8, 6.3)
9,12,13-TriHOME				7.8 (6.4, 13.8)	10.3 (3.8, 14.9)	14.1 (7.6, 25.4)
Total TriHOME				9.5 (7.8, 16.7)	12.2 (5.1, 18.2)	17.9 (9.3, 31.7)
EKODE				13.0 (9.1, 16.4)	16.5 (10.6, 24.2)	21.6 (14.0, 27.1)
DGLA
15(S)-HETrE	3.4 (1.4, 8.0)	2.3 (0.6, 4.0)	3.1 (0.5, 7.6)	3.9 (2.8, 4.6)	4.6 (0.8, 7.7)	2.1 (1.5, 4.1)
AA
5-HETE	23.5 (18.1, 35.9)	80.8 (68.5, 108.4)	138.0 (43.8, 212.6)	2.9 (2.3, 3.5)	5.8 (4.6, 8.3)	5.2 (4.4, 10.3)
8-HETE	26.5 (16.1, 33.5)	28.0 (16.7, 34.3)	33.6 (13.8, 57.9)	2.2 (0.4, 8.0)	6.1 (1.7, 13.6)	3.2 (1.1, 6.7)
12-HETE	13.5 (9.8, 24.5)	42.2 (30.8, 56.6)	64.1 (15.5, 123.5)	8.0 (3.7, 14.9)^a	59.3 (24.1, 77.3)^b	29.2 (20.1, 57.3)^b
15-HETE	22.0 (13.4, 33.8)	54.9 (33.2, 71.9)	79.0 (18.4, 138.3)	5.8 (2.1, 8.0)	11.7 (5.8, 20.5)	8.5 (6.1, 11.9)
20-HETE	20.3 (6.5, 32.9)	14.1 (12.3, 21.1)	16.5 (4.0, 43.7)	9.4 (6.6, 15.6)	5.1 (2.0, 17.4)	5.6 (3.4, 10.3)
5-oxo-ETE	15.9 (3.4, 25.2)	27.5 (22.7, 37.8)	41.9 (2.3, 65.9)	9.3 (6.1, 15.9)	10.4 (6.2, 16.5)	4.5 (2.3, 17.6)
15-oxo-ETE	9.9 (5.5, 11.7)^a	36.2 (24.6, 62.9)^b	35.6 (8.4, 91.1)^ab	2.1 (1.1, 3.1)^a	11.6 (4.8, 14.8)^b	6.4 (4.5, 12.0)^b
5(6)-EpETrE	19.7 (11.2, 92.1)	83.4 (32.0, 197.9)	85.3 (66.8, 307.4)
8(9)-EpETrE	0.5 (0.3, 1.2)	0.8 (0.4, 1.3)	0.7 (0.5, 1.0)
11(12)-EpETrE	277.1 (109.6, 514.7)	951.9 (409.7, 2,399.3)	596.3 (332.0, 2,079.0)	3.3 (1.9, 9.9)^a	20.2 (12.6, 73.8)^b	31.6 (14.2, 84.7)^b
14(15)-EpETrE	400.9 (165.8, 1,157.2)	1,821.9 (812.5, 5,082.1)	1,193.8 (620.0, 4,524.4)	2.9 (0.9, 4.1)^a	14.5 (7.3, 34.7)^b	17.3 (10.8, 52.6)^b
5,6-DiHETrE	2.4 (2.2, 2.9)^a	10.0 (6.5, 15.6)^b	13.1 (9.4, 16.2)^b	0.1 (0.0, 0.3)	0.2 (0.2, 0.5)	0.4 (0.1, 0.5)
8,9-DiHETrE	0.7 (0.3, 1.1)^a	2.3 (1.4, 2.8)^b	1.1 (0.8, 1.9)^ab
11,12-DiHETrE	0.6 (0.5, 1.0)	2.1 (0.9, 3.5)	1.6 (1.1, 2.3)	0.4 (0.1, 0.6)^a	1.1 (0.8, 1.3)^b	1.1 (0.7, 2.1)^b
14,15-DiHETrE	0.5 (0.2, 0.8)^a	2.8 (2.0, 4.2)^b	2.8 (2.2, 4.7)^b	0.3 (0.2, 1.0)^a	1.8 (1.3, 2.4)^b	1.9 (1.4, 2.1)^b
TXB2	0.5 (0.4, 0.8)^a	1.8 (1.3, 3.2)^b	1.9 (1.2, 2.1)^b	0.4 (0.3, 0.8)^a	1.6 (1.3, 2.0)^b	1.6 (1.1, 3.2)^b
LTB3	3.1 (1.2, 4.1)	1.7 (0.6, 3.0)	2.4 (0.4, 4.9)
LTB4	1.3 (0.1, 4.1)	0.1 (0.0, 1.1)	0.2 (0.1, 1.2)
6-trans-LTB4	1.6 (0.0, 5.4)	0.7 (0.0, 3.4)	1.6 (0.3, 2.6)
20-COOH-LTB4	14.2 (7.3, 25.8)	14.7 (10.3, 23.1)	12.5 (9.0, 35.6)	3.2 (1.3, 5.0)	2.0 (1.2, 3.4)	3.9 (1.6, 6.0)
20-OH-LTB4	1.6 (1.4, 1.8)	0.7 (0.0, 1.7)	1.5 (0.2, 3.2)
LXA4	5.8 (2.1, 6.7)^a	0.7 (0.5, 1.8)^b	0.3 (0.1, 1.8)^b	0.3 (0.1, 0.5)	0.1 (0.0, 0.3)	0.3 (0.2, 0.5)
11,12,15-TriHETrE				0.3 (0.2, 0.4)	0.4 (0.3, 0.5)	0.5 (0.4, 0.8)
n-3 Derivatives α-LNA
9-HOTrE	2.3 (0.2, 6.3)	1.8 (0.3, 2.8)	2.2 (1.4, 2.7)	7.3 (1.6, 11.0)	2.7 (1.9, 5.4)	3.0 (2.4, 6.4)
9(10)-EpODE	26.2 (18.7, 103.1)	12.4 (6.9, 36.9)	12.5 (8.8, 31.3)	15.1 (9.3, 29.1)	13.4 (9.1, 42.3)	30.1 (8.6, 74.2)
12(13)-EpODE	55.4 (19.5, 116.6)	30.1 (11.4, 45.3)	11.7 (6.0, 53.8)	5.8 (3.6, 16.0)	4.3 (2.7, 19.1)	10.0 (3.5, 30.6)
15(16)-EpODE	466.4 (145.3, 790.0)	217.2 (78.2, 328.6)	99.7 (63.3, 375.7)	34.8 (14.1, 57.1)	24.9 (19.8, 67.2)	45.2 (18.1, 110.4)
15,16-DiHODE	3.8 (3.1, 4.8)	4.2 (3.5, 5.9)	4.6 (3.9, 6.3)	3.8 (3.2, 5.8)	3.2 (2.6, 3.7)	3.6 (2.9, 4.8)
EPA
5-HEPE	62.4 (31.7, 72.8)^a	10.4 (4.4, 14.9)^b	6.3 (2.8, 16.2)^b	9.5 (4.7, 14.4)^a	1.4 (0.9, 4.2)^ab	1.6 (0.3, 1.7)^b
12-HEPE	2,284.6 (683.6, 3,233.9)^a	145.4 (80.6, 338.1)^b	25.8 (0.1, 66.3)^b
15-HEPE	6.3 (4.9, 13.4)	3.9 (1.6, 6.6)	2.7 (0.1, 5.7)	9.9 (6.6, 15.2)^a	4.7 (1.3, 11.9)^ab	3.5 (2.2, 4.2)^b
8(9)-EpETE	41.9 (19.3, 140.5)^a	2.9 (1.0, 11.1)^ab	0.0 (0.0, 1.4)^b
11(12)-EpETE	171.4 (57.1, 267.0)^a	8.9 (5.2, 21.9)^b	4.0 (1.4, 5.1)^b	6.4 (4.8, 10.5)^a	1.0 (0.3, 2.7)^b	1.5 (0.8, 3.2)^b
14(15)-EpETE	293.9 (131.8, 559.8)^a	23.0 (6.4, 53.9)^b	3.9 (3.1, 21.7)^b	3.9 (3.7, 6.0)	3.0 (1.3, 5.2)	1.1 (0.4, 3.4)
17(18)-EpETE	382.5 (220.8, 803.9)^a	29.5 (10.9, 93.1)^b	10.9 (7.4, 19.1)^b
Total EpETE	951.2 (431.2, 1,712.8)^a	62.9 (26.0, 190.0)^b	18.2 (13.1, 46.5)^b	9.9 (8.6, 15.4)^a	4.6 (2.4, 7.3)^b	2.2 (1.6, 9.3)^b
5,15-DiHETE	0.8 (0.5, 1.6)	0.9 (0.3, 1.7)	1.7 (0.9, 2.0)
8,15-DiHETE	0.7 (0.3, 1.1)^a	2.3 (1.4, 2.8)^b	1.1 (0.8, 1.9)^ab
17,18-DiHETE	1.7 (1.0, 3.6)^a	0.7 (0.3, 1.0)^ab	0.5 (0.3, 0.8)^b	3.7 (3.1, 4.2)^a	0.8 (0.3, 1.2)^b	0.4 (0.2, 0.8)^b
PGD3				0.7 (0.4, 1.0)	0.4 (0.3, 0.6)	0.4 (0.4, 0.6)
PGE3				0.1 (0.1, 0.2)	0.1 (0.1, 0.2)	0.1 (0.0, 0.1)
DHA
7(8)-EpDPE	1346.7 (627.4, 4,955.1)	489.8 (386.9, 941.5)	515.8 (199.5, 1,132.4)	96.2 (46.4, 187.1)	139.8 (47.5, 301.8)	108.8 (30.2, 260.8)
10(11)-EpDPE	155.1 (37.6, 345.1)	75.7 (29.3, 112.0)	31.3 (19.8, 114.2)	8.3 (4.4, 11.1)	6.0 (3.8, 17.3)	3.2 (2.8, 9.7)
13(14)-EpDPE	218.8 (78.7, 417.7)	103.6 (29.8, 245.8)	42.6 (19.8, 189.3)	2.8 (1.4, 4.1)	4.5 (1.0, 9.7)	1.0 (0.3, 4.4)
16(17)-EpDPE	236.8 (75.9, 524.5)	133.8 (46.9, 332.6)	48.7 (31.8, 234.1)
19(20)-EpDPE	504.3 (164.2, 1,047.8)	231.9 (95.6, 722.6)	133.4 (67.0, 448.5)	3.5 (2.8, 4.6)	6.6 (1.5, 21.0)	3.0 (0.9, 10.1)
Total EpDPE	2,851.7 (1,074.4, 6,809.5)	1,241.8 (588.6, 2,201.9)	696.8 (401.6, 2,118.5)	105.6 (55.4, 204.6)	157.4 (61.3, 339.4)	119.0 (34.6, 281.4)
17-HDoHE	14.5 (8.7, 35.6)	3.1 (1.9, 13.2)	6.0 (1.3, 17.1)	5.1 (4.2, 8.4)	4.7 (0.6, 7.1)	2.8 (1.3, 5.6)
10,11-DiHDPE				0.7 (0.4, 0.9)^a	0.2 (0.1, 0.4)^ab	0.2 (0.1, 0.3)^b
13,14-DiHDPE				0.4 (0.3, 0.4)^a	0.2 (0.2, 0.4)^ab	0.1 (0.1, 0.3)^b
16,17-DiHDPE	1.0 (0.6, 1.6)	0.9 (0.6, 1.7)	1.0 (0.5, 1.5)	1.3 (0.7, 2.2)^a	0.5 (0.3, 1.0)^ab	0.4 (0.3, 0.7)^b
19,20-DiHDPE	6.8 (4.4, 9.6)	2.5 (1.3, 4.2)	2.6 (1.3, 4.5)	3.3 (2.3, 6.5)^a	2.1 (1.5, 3.7)^ab	1.6 (1.2, 2.0)^b

Data are presented as median and interquartile ranges (IQR) of n=8 per group. The lower and upper boundaries of the IQR represent 25th and 75^th percentile values, respectively. Data were analyzed by Kruskal Wallis one-way analysis of variance (ANOVA) followed by Dunn’s post-hoc test. Different alphabetical superscripts mean that the groups differed significantly (P<0.05) from each other.