Table 4.

Plasma and cortex oxylipins that changed significantly in the total or unesterified pools

	TOTAL		UNESTERIFIED
	Plasma	Cortex	Plasma	Cortex
n-6 Derivatives LA
9-HODE	↔	↑(10.5%)	↔	↑(10.5%)
13-HODE	↔	↑(10.5%)	↔	↑(10.5%)
Total HODE	↔	↑(10.5%)	↔	↑(10.5%)
9-oxo-ODE	↔	↔	↔	↑(10.5%)
9(10)-EpOME	↔	↑(10.5%)	↑↑	↑(10.5%)
12(13)-EpOME	↔	↔	↑↑	↑(10.5%)
Total EpOME	↔	↑(10.5%)	↑↑	↑(10.5%)
9,10-DiHOME	↑↑	↑(10.5%)	↑(10.5%)	↑(10.5%)
12,13-DiHOME	↑↑	↑(10.5%)	↑↑	↑(10.5%)
Total DiHOME	↑↑	↑(10.5%)	↑(10.5%)	↑(10.5%)
9,10,13-TriHOME	ND	ND	↔	↑(10.5%)
9,12,13-TriHOME	ND	ND	↔	↑(10.5%)
Total TriHOME	ND	ND	↔	↑(10.5%)
AA
5-HETE	↔	↔	↔	↔
12-HETE	↔	↔	↑↑	↔
15-oxo-ETE	↑(5.2%)	↔	↑↑	↔
11(12)-EpETrE	↔	↔	↑↑	↔
14(15)-EpETrE	↔	↔	↑↑	↔
5,6-DiHETrE	↑↑	↔	↔	↔
8,9-DiHETrE	↑(5.2%)	↑(10.5%)	ND	↔
11,12-DiHETrE	↔	↔	↑↑	↑(10.5%)
14,15-DiHETrE	↑↑	↔	↑↑	↑(10.5%)
PGD2	ND	ND	ND	↑(10.5%)
TXB2	↑↑	↔	↑↑	↔
LXA4	↓↓	ND	↔	ND
n-3 Derivatives EPA
5-HEPE	↓↓	↓↓	↓(10.5%)	↓↓
12-HEPE	↓↓	↔	ND	↔
15-HEPE	↔	↓↓	↓(10.5%)	↓(10.5%)
8(9)-EpETE	↓(10.5%)	↓↓	ND	↓↓
11(12)-EpETE	↓↓	↔	↓↓	↔
14(15)-EpETE	↓↓	↓↓	↔	↓↓
17(18)-EpETE	↓↓	↓↓	ND	↓↓
Total EpETE	↓↓	↓↓	↓↓	↓↓
8,15-DiHETE	↑(5.2%)	↔	ND	↔
17,18-DiHETE	↓(10.5%)	↓↓	↓↓	↓↓
PGE3	ND	ND	↔	↓↓
DHA
10,11-DiHDPE	ND	↔	↓(10.5%)	↔
13,14-DiHDPE	ND	↔	↓ (10.5%)	↔
16,17-DiHDPE	↔	↔	↓(10.5%)	↔
19,20-DiHDPE	↔	↔	↓(10.5%)	↔

One arrow means that the 5.2% and/or 10.5% LA group differed significantly from 0.4% LA controls. Parenthesis indicate the specific group (5.2% or 10.5%) that differed from the 0.4% LA group. Two arrows mean that both the 5.2% and 10.5% LA groups differed significantly from 0.4% LA. A left-right arrow (↔) means that there were no significant differences between any groups. ND means that the metabolites were not detected.