Fig. 2. Comparison of HPV, basal PAP, and Ang II-induced ΔPAP in V/P lungs of the control, PAH-MCT, and PAH-CH rats.
(A~C) Representative traces of PAP recording in the control (A), PAH-MCT (B), and PAH-CH (C) rats. The basal PAP significantly increased in the PAH-MCT rats. The hypoxic ventilation (3% Po2)-induced PAP increase (ΔPAPHypoxia) was robust in the PAH-MCT rats, whereas HPV was abolished in the PAH-CH rats. The Ang II-induced contraction also improved in the PAH-MCT rats. (D~F) Summaries of Ang II-induced ΔPAP (D), basal PAP (E), and ΔPAPHypoxia (F) are shown as bar graphs comparing the results among the three groups. ***p<0.001.