Fig. 3.

Anatomical depiction of retrograde and anterograde trans-synaptic degeneration in the visual pathway. a Diagrammatic representation of the organisation of the anterior (retina, optic nerve, chiasm, optic tracts and LGN) and posterior (optic radiations and visual cortex) visual pathway. b Retrograde trans-synaptic degeneration describes the process through which damage to the posterior visual pathway (black) results in subsequent retinal degeneration. c Anterograde trans-synaptic degeneration describes a process where retinal degeneration leads to a subsequent degeneration of the posterior visual pathway